Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides

doi:10.1016/j.algal.2021.102312

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物资源高效利用研究与发展中心

	Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides
	Li, Ke 1,2; Li, Xiao-Ming 1; Gloer, James B.3; Wang, Bin-Gui 1,2,4
刊名	ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
	2021-06-01
卷号	56 页码:5
关键词	Marine red alga Rhodomela confervoides Ureidobromophenols Antioxidant activity
ISSN号	2211-9264
DOI	10.1016/j.algal.2021.102312
通讯作者	Li, Ke(kli@yic.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
英文摘要	An extensive investigation on the chemical components with potential antioxidant activity resulted in the characterization of four new ureidobromophenols (1-4) and two related metabolites (5 and 6) from ethyl acetate extract of the marine red alga Rhodomela confervoides. Their structures were determined using spectroscopic analysis and comparisons with known compounds. Compound 1 possesses unique structure of an ureido group bearing gamma-butyric acid and 2,3-dibromo-4,5-dihydroxybenzyl moieties on the same nitrogen atom. Compounds 1-4 displayed significant antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals with IC50 values ranging from 3.34 to 4.84 mu M, which are more active than that of the positive controls ascorbic acid (IC50 = 20.1 mu M) and butylated hydroxytoluene (IC50 = 82.1 mu M). These compounds also exhibited potent activity against 2,2' -azino-bis(3-ethylbenzothiazoline-6-sulphonate (ABTS) radicals with trolox equivalent antioxidant capacity (TEAC) values ranging from 3.25 to 5.01 mM, which are 3- to 5-fold potent than that of ascorbic acid (TEAC = 1.02 mM). The antioxidant activity of ureidobromophenols isolated from marine alga might boost the seaweed functional food ingredients or dietary food supplements in food industry.
资助项目	Natural Science Foundation of China[31330009] ; Shuangbai Plan of Yantai Municipal City[20183] ; Taishan Scholar Project from Shandong Province of China
WOS关键词	INDUCED OXIDATIVE STRESS ; FUNCTIONAL FOODS ; IN-VITRO ; BROMOPHENOLS ; FRACTIONS ; CAPACITY ; EXTRACT
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
WOS记录号	WOS:000663410100019
资助机构	Natural Science Foundation of China ; Shuangbai Plan of Yantai Municipal City ; Taishan Scholar Project from Shandong Province of China
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/29430]
专题	海岸带生物资源高效利用研究与发展中心
通讯作者	Li, Ke; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Inst Oceanol,Lab Marine Biol & Biotechnol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Univ Iowa, Dept Chem, Iowa City, IA 52242 USA 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Li, Ke,Li, Xiao-Ming,Gloer, James B.,et al. Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides[J]. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,2021,56:5.
APA	Li, Ke,Li, Xiao-Ming,Gloer, James B.,&Wang, Bin-Gui.(2021).Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides.ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,56,5.
MLA	Li, Ke,et al."Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides".ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS 56(2021):5.