Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive I-125 seed

doi:10.1007/s10967-021-07984-6

	Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive I-125 seed
	Liu, Fang 2,3; Bao, Jie 2,4; Chen, Jinwu 2,5; Song, Wencheng 1,2,4,6
刊名	JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
	2021-09-18
关键词	I-125 seed Transcriptome Inhibitory mechanism A549 cells
ISSN号	0236-5731
DOI	10.1007/s10967-021-07984-6
通讯作者	Chen, Jinwu(yunliuqiye@163.com) ; Song, Wencheng(wencsong@cmpt.ac.cn)
英文摘要	In this study, A549 cells treated by radioactive I-125 seed were sequenced using Illumina HiSeq PE150, and then the transcriptome was analyzed using bioinformatics methods. Gene ontology classification analysis showed that differentially expressed genes (DEGs) belonged to 10 categories, and low-dose group, medium-dose group and high-dose group I-125 treatment obtained 440 DEGs, 4275 DEGs and 2850 DEGs, respectively. Additionally, DEGs were involved in tumor-related pathways, endoplasmic reticulum protein processing and cell cycle pathways. Therefore, radioactive I-125 seed can significantly inhibit the growth of lung cancer, which provide a theoretical basis for the clinical I-125 seed to effectively treat lung cancer.
资助项目	National Natural Science Foundation of China[21876179] ; National Natural Science Foundation of China[22142007] ; National Natural Science Foundation of China[22006001] ; Natural Science Foundation of Anhui Province[1808085QA13] ; Natural Science Foundation of Anhui Province[2008085MC65] ; China Postdoctoral Science Foundation[2020T130117ZX] ; China Postdoctoral Science Foundation[2020M671914] ; China Postdoctoral Science Foundation[2020B470] ; Natural Science Foundation of Anhui Higher Education Institutions[KJ2017A935]
WOS关键词	AMERICAN BRACHYTHERAPY ; RADIATION ; IMPLANTATION ; IRRADIATION ; EXPRESSION ; APOPTOSIS ; TUMORS
WOS研究方向	Chemistry ; Nuclear Science & Technology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000697093300004
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; China Postdoctoral Science Foundation ; Natural Science Foundation of Anhui Higher Education Institutions
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125313]
专题	中国科学院合肥物质科学研究院
通讯作者	Chen, Jinwu; Song, Wencheng
作者单位	1.Soochow Univ, Sch Radiol & Interdisciplinary Sci, Suzhou 215123, Peoples R China 2.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 3.Anhui Univ, Sch Life Sci, Hefei 230036, Peoples R China 4.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China 5.Hefei Normal Univ, Hefei 230061, Anhui, Peoples R China 6.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215123, Peoples R China
推荐引用方式 GB/T 7714	Liu, Fang,Bao, Jie,Chen, Jinwu,et al. Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive I-125 seed[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2021.
APA	Liu, Fang,Bao, Jie,Chen, Jinwu,&Song, Wencheng.(2021).Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive I-125 seed.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY.
MLA	Liu, Fang,et al."Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive I-125 seed".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY (2021).