Pulmonary enteric adenocarcinoma

doi:10.1016/j.tranon.2021.101123

	Pulmonary enteric adenocarcinoma
	Gong, Jiali 1,2,3,4; Fan, Ying 2,3,4,5; Lu, Hongyang 1,2,3,4
刊名	TRANSLATIONAL ONCOLOGY
	2021-08-01
卷号	14
关键词	PEAC Immunohistochemistry Mutation analysis Diagnosis Prognosis
ISSN号	1936-5233
DOI	10.1016/j.tranon.2021.101123
通讯作者	Lu, Hongyang(luhy@zjcc.org.cn)
英文摘要	Pulmonary enteric adenocarcinoma (PEAC) is an exceptionally rare subtype of non-small cell lung cancer (NSCLC). It is characterized by pathological features similar to those of colorectal adenocarcinoma. Most patients with PEAC have almost no special clinical manifestations, and it is often difficult to differentiate from metastatic colorectal adenocarcinoma (MCRC). As a special type of lung adenocarcinoma, PEAC has unique mutation expres-sion and immune characteristics; its mutation profile shows higher Kirsten rat sarcoma viral oncogene (KRAS), human epidermal growth factor receptor-2 (HER2) , DNA mismatch repair(MMR) mutation rates, and much lower epidermal growth factor receptor (EGFR) rate. So in the future, targeted therapy may tend to be a new light in the treatment of PEAC. As for immunohistochemistry (IHC), CDX-2, villin, and CK7 are significantly positive in PEAC. This review focuses on the pathologic features, immunohistochemical examination, mutation analysis, diagnosis, treatment, and prognosis of PEAC.
资助项目	Zhejiang Province Medical Science and Technology Project[2020ZH001] ; CSCO Haosen Cancer Research Foundation[Y-HS2017-044]
WOS关键词	CDX-2 HOMEOBOX GENE ; INTESTINAL-TYPE ; LUNG ; EXPRESSION ; CARCINOMAS ; DIFFERENTIATION ; MARKER ; CANCER ; SATB2 ; CYTOKERATIN-20
WOS研究方向	Oncology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000687271300017
资助机构	Zhejiang Province Medical Science and Technology Project ; CSCO Haosen Cancer Research Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125235]
专题	中国科学院合肥物质科学研究院
通讯作者	Lu, Hongyang
作者单位	1.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310053, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Zhejiang Key Lab Diag & Treatment Technol Thorac, Hangzhou 310022, Zhejiang, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Med Oncol, Hangzhou 310022, Zhejiang, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Zhejiang, Peoples R China 5.Wenzhou Med Univ, Clin Med Coll 1, Wenzhou 325035, Peoples R China
推荐引用方式 GB/T 7714	Gong, Jiali,Fan, Ying,Lu, Hongyang. Pulmonary enteric adenocarcinoma[J]. TRANSLATIONAL ONCOLOGY,2021,14.
APA	Gong, Jiali,Fan, Ying,&Lu, Hongyang.(2021).Pulmonary enteric adenocarcinoma.TRANSLATIONAL ONCOLOGY,14.
MLA	Gong, Jiali,et al."Pulmonary enteric adenocarcinoma".TRANSLATIONAL ONCOLOGY 14(2021).