Upconversion-based dual-mode optical nanosensor for highly sensitive and colorimetric evaluation of heparin in serum

doi:10.1016/j.snb.2021.130378

	Upconversion-based dual-mode optical nanosensor for highly sensitive and colorimetric evaluation of heparin in serum
	Zhu, Jiawei 1,3; Hu, Bin 1,3; Yang, Liang 2,3; Jiang, Changlong 2,3
刊名	SENSORS AND ACTUATORS B-CHEMICAL
	2021-10-15
卷号	345
关键词	Upconversion-based nanosensor Dual-mode probe Visual quantitative sensing Smartphone-sensing platform Heparin
DOI	10.1016/j.snb.2021.130378
通讯作者	Yang, Liang(yangliang@iim.ac.cn) ; Jiang, Changlong(cljiang@iim.ac.cn)
英文摘要	Heparin is an important anticoagulant in clinics, which requires regular detection and dose adjustment. Fluo-rimetry is a powerful tool considering the advantages of fast response and high sensitivity while most fluorescent sensors suffer from spontaneous fluorescence for excitation under short-wavelength light, the occurrence of false positives, complex and time-consuming preparation, as well as expensive detection instruments. Herein, we developed upconversion nanoparticles (UCNPs) based nanosensor for fluorescent and colorimetric detection of heparin. The nanosensor exhibited sensitive detection for heparin with the low limit of detection (LOD) of 0.1 nM in fluorescent mode and 0.3 nM in colorimetric mode. In addition, we used a smartphone-sensing platform for quantitative detection of heparin with the LOD of 2 nM. Depending on long-wavelength excitation and fluorescent-colorimetric dual-response detection signal, the designed nanosensor could eliminate the auto-fluorescence, which effectively increased the accuracy of the sensor, thus extending the applications for bed -side heparin assay and related medical safety.
资助项目	National Natural Science Foundation of China[21671052] ; National Natural Science Foundation of China[21806168] ; Key Research and Development Program of Anhui Province[202004d07020013] ; Key Research and Development Program of Anhui Province[1804a07020103]
WOS关键词	FLUORESCENCE SENSOR ; NANOPARTICLES ; CONTRAST ; PLATFORM
WOS研究方向	Chemistry ; Electrochemistry ; Instruments & Instrumentation
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000685514600005
资助机构	National Natural Science Foundation of China ; Key Research and Development Program of Anhui Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/124410]
专题	中国科学院合肥物质科学研究院
通讯作者	Yang, Liang; Jiang, Changlong
作者单位	1.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Photovolta & Energy Conservat Mat, Hefei 230031, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Jiawei,Hu, Bin,Yang, Liang,et al. Upconversion-based dual-mode optical nanosensor for highly sensitive and colorimetric evaluation of heparin in serum[J]. SENSORS AND ACTUATORS B-CHEMICAL,2021,345.
APA	Zhu, Jiawei,Hu, Bin,Yang, Liang,&Jiang, Changlong.(2021).Upconversion-based dual-mode optical nanosensor for highly sensitive and colorimetric evaluation of heparin in serum.SENSORS AND ACTUATORS B-CHEMICAL,345.
MLA	Zhu, Jiawei,et al."Upconversion-based dual-mode optical nanosensor for highly sensitive and colorimetric evaluation of heparin in serum".SENSORS AND ACTUATORS B-CHEMICAL 345(2021).