An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth

doi:10.1016/j.tranon.2021.101103

	An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth
	Yang, Xingxing 2,3; Song, Chao 2,3; Zhang, Lei 2; Wang, Junjun 2,4; Yu, Xin 2,3; Yu, Biao 2,3; Zablotskii, Vitalii 1,5; Zhang, Xin 1,2,3,4
刊名	TRANSLATIONAL ONCOLOGY
	2021-07-01
卷号	14
关键词	9 4 T static magnetic field (SMF) Lung cancer Cell cycle P53 ROS
ISSN号	1936-5233
DOI	10.1016/j.tranon.2021.101103
通讯作者	Zhang, Xin(xinzhang@hmfl.ac.cn)
英文摘要	Studies have shown that 9.4 Tesla (9.4 T) high-field magnetic resonance imaging (MRI) has obvious advantages in improving image resolution and capacity, but their safety issues need to be further validated before their clinical approval. Meanwhile, emerging experimental evidences show that moderate to high intensity Static Magnetic Fields (SMFs) have some anti-cancer effects. We examined the effects of two opposite SMF directions on lung cancer bearing mice and found when the lung cancer cell-bearing mice were treated with 9.4 T SMFs for 88 h in total, the upward 9.4 T SMF significantly inhibited A549 tumor growth (tumor growth inhibition = 41%), but not the downward 9.4 T SMF. In vitro cellular analysis shows that 9.4 T upward SMF treatment for 24 h not only inhibited A549 DNA synthesis, but also significantly increased ROS and P53 levels, and arrested G2 cell cycle. Moreover, the 9.4 T SMF-treatments for 88 h had no severe impairment to the key organs or blood cell count of the mice. Our findings demonstrated the safety of 9.4 T SMF long-term exposure for their future applications in MRI, and revealed the anti-cancer potential of the upward direction 9.4 T SMF.
资助项目	National Key R&D Program of China[2016YFA0400900] ; National Natural Science Foundation of China[31900506] ; CASHIPS Director's Fund[YZJJ201704] ; CASHIPS Director's Fund[KP-2017-26] ; Heye Health Technology Foundation[HYJJ20190801] ; National Science Foundation for Young Scientists of China[31900506] ; National Science Foundation of Anhui Province[1908085MA11] ; China Postdoctoral Science Foundation[2019M652222]
WOS关键词	HUMAN BRAIN ; P53 ; CELLS ; REPLICATION ; ORIENTATION ; EXPOSURE ; PATHWAY ; MRI
WOS研究方向	Oncology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000663384600009
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China ; CASHIPS Director's Fund ; Heye Health Technology Foundation ; National Science Foundation for Young Scientists of China ; National Science Foundation of Anhui Province ; China Postdoctoral Science Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/123944]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Xin
作者单位	1.Int Magnetobiol Frontier Res Ctr iMFRC, Sci Isl, Prague 230031, Czech Republic 2.Chinese Acad Sci, Hefei Inst Phys Sci, CAS Key Lab High Magnet Field & Ion Beam Phys Bio, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China 3.Univ Sci & Technol China, Sci Isl Branch, Grad Sch, Hefei 230026, Anhui, Peoples R China 4.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China 5.Czech Acad Sci, Inst Phys, Prague 18221, Czech Republic
推荐引用方式 GB/T 7714	Yang, Xingxing,Song, Chao,Zhang, Lei,et al. An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth[J]. TRANSLATIONAL ONCOLOGY,2021,14.
APA	Yang, Xingxing.,Song, Chao.,Zhang, Lei.,Wang, Junjun.,Yu, Xin.,...&Zhang, Xin.(2021).An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth.TRANSLATIONAL ONCOLOGY,14.
MLA	Yang, Xingxing,et al."An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth".TRANSLATIONAL ONCOLOGY 14(2021).