Preliminary assessment of genotoxic effects induced by radiation from EAST using Vicia faba micronucleus assay

doi:10.1088/1361-6498/abe0d1

	Preliminary assessment of genotoxic effects induced by radiation from EAST using Vicia faba micronucleus assay
	Zhang, Hong 1,2; Hu, Liqun 1; Zhong, Guoqiang 1; Huo, Zhipeng 1; Chen, Yuqing 1; Zhao, Sheng 1,3; Huang, Liangsheng 1,3
刊名	JOURNAL OF RADIOLOGICAL PROTECTION
	2021-06-01
卷号	41
关键词	EAST genotoxic effects radiation protection micronucleus assay Vicia faba
ISSN号	0952-4746
DOI	10.1088/1361-6498/abe0d1
通讯作者	Zhang, Hong(hong.zhang@ipp.ac.cn)
英文摘要	During long-pulse deuterium plasma operations in the Experimental Advanced Superconducting Tokamak (EAST), a mixed radiation field is generated, which is mainly composed of fusion neutrons, gamma rays, and x-rays. More accurate and effective dose monitoring methods have been developed and established to determine the ionizing radiation intensity both for the stable operation of the device and for the radiation safety of personnel. As far as we know, there are few reports about the biological effects of radiation induced by fusion neutrons and gamma radiation, which are of vital importance for the assessment of radiation hazards presented by fusion devices, such as EAST, to human beings and the environment. In this study, three positions in the EAST hall were selected to detect genotoxic effects induced by nuclear fusion radiation using a Vicia faba micronucleus (MN) test for the first time. The doses of neutrons and gamma rays at these places were measured by thermoluminescence dosimeters four times between June 2019 and May 2020. The radiation doses decreased as the distances from the EAST device shell gradually increased from S1 to S3. The radiation in the EAST hall resulted in a significant induction of MN in the Vicia faba root tip cells compared to a negative control, which was different from the MN frequency induced by fission neutrons, gamma-rays and other kinds of radiation in previous studies. These results indicate the existence of potential genotoxic effects induced by radiation from EAST which is different from other radiation and suggest that personnel should not be permitted to enter the experimental hall during the discharge process, and that radiation protection measures should be taken during necessary maintenance to avoid radiation damage. These newly acquired results will certainly increase our knowledge about the biological effects induced by radiation from nuclear fusion and provide good data support for developing more effective environmental and personnel fusion radiation protection.
资助项目	National Natural Science Foundation of China[21777165] ; National Natural Science Foundation of China[11605241] ; National Natural Science Foundation of China[11705229] ; National Key Research and Development Program of China[2017YFE0300503] ; Users with Excellence Program of Hefei Science Center CAS[2020HSC-UE012]
WOS关键词	GAMMA-RAYS ; FISSION NEUTRONS ; INDUCTION ; SINGLE ; OXYGEN ; ROOTS ; FIELD
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	IOP PUBLISHING LTD
WOS记录号	WOS:000657111900001
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Users with Excellence Program of Hefei Science Center CAS
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/123653]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Hong
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Plasma Phys, POB 1126,350 Shushanhu Rd, Hefei 230031, Peoples R China 2.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Sci Isl Branch, Grad Sch, Hefei 230026, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hong,Hu, Liqun,Zhong, Guoqiang,et al. Preliminary assessment of genotoxic effects induced by radiation from EAST using Vicia faba micronucleus assay[J]. JOURNAL OF RADIOLOGICAL PROTECTION,2021,41.
APA	Zhang, Hong.,Hu, Liqun.,Zhong, Guoqiang.,Huo, Zhipeng.,Chen, Yuqing.,...&Huang, Liangsheng.(2021).Preliminary assessment of genotoxic effects induced by radiation from EAST using Vicia faba micronucleus assay.JOURNAL OF RADIOLOGICAL PROTECTION,41.
MLA	Zhang, Hong,et al."Preliminary assessment of genotoxic effects induced by radiation from EAST using Vicia faba micronucleus assay".JOURNAL OF RADIOLOGICAL PROTECTION 41(2021).