Role of Mitochondrial Dysfunction in the Pathology of Amyloid-beta

doi:10.3233/JAD-200519

	Role of Mitochondrial Dysfunction in the Pathology of Amyloid-beta
	Huang, Zhenting 1,2; Yan, Qian 1,2,4; Wang, Yangyang 1,2; Zou, Qian 1,2; Li, Jing 1,2; Liu, Zhou 3; Cai, Zhiyou 1,2
刊名	JOURNAL OF ALZHEIMERS DISEASE
	2020
卷号	78 期号:2 页码:505-514
关键词	Alzheimer's disease amyloid-beta dysfunction mitochondria pathology
ISSN号	1387-2877
DOI	10.3233/JAD-200519
通讯作者	Liu, Zhou(liuzhou@gdmu.edu.cn) ; Cai, Zhiyou(caizhiyou@ucas.ac.cn)
英文摘要	Mitochondrial dysfunction has been widely reported in several neurodegenerative disorders, including in the brains of patients with Alzheimer's disease (AD), Parkinson's disease, and Huntington disease. An increasing number of studies have implicated altered glucose and energy metabolism in patients with AD. There is compelling evidence of abnormalities in some of the key mitochondrial enzymes involved in glucose metabolism, including the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes, which play a great significance role in the pathogenesis of AD. Changes in some of the enzyme activities of the mitochondria found in AD have been linked with the pathology of amyloid-beta (A beta). This review highlights the role of mitochondrial function in the production and clearance of A beta and how the pathology of A beta leads to a decrease in energy metabolism by affecting mitochondrial function.
资助项目	Chongqing Natural Science Foundation[cstc2018jc yjAX0602] ; Chongqing Health Commission[2018ZDXM004] ; Science and Technology Planning Project of Yuzhong District of Chongqing[20180104] ; Chongqing Health and Family Planning Scientific Research Project[ZY201702042]
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	IOS PRESS
WOS记录号	WOS:000592248100002
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/12615]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Liu, Zhou; Cai, Zhiyou
作者单位	1.Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Neurol, 312 Zhongshan First Rd, Chongqing 400013, Peoples R China 2.Chongqing Key Lab Neurodegenerat Dis, Chongqing, Peoples R China 3.Guangdong Med Univ, Dept Neurol, Guangdong Key Lab Age Related Cardiac & Cerebral, Affiliated Hosp, Zhanjiang, Guangdong, Peoples R China 4.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China
推荐引用方式 GB/T 7714	Huang, Zhenting,Yan, Qian,Wang, Yangyang,et al. Role of Mitochondrial Dysfunction in the Pathology of Amyloid-beta[J]. JOURNAL OF ALZHEIMERS DISEASE,2020,78(2):505-514.
APA	Huang, Zhenting.,Yan, Qian.,Wang, Yangyang.,Zou, Qian.,Li, Jing.,...&Cai, Zhiyou.(2020).Role of Mitochondrial Dysfunction in the Pathology of Amyloid-beta.JOURNAL OF ALZHEIMERS DISEASE,78(2),505-514.
MLA	Huang, Zhenting,et al."Role of Mitochondrial Dysfunction in the Pathology of Amyloid-beta".JOURNAL OF ALZHEIMERS DISEASE 78.2(2020):505-514.