Photodynamic Nanophotosensitizers: Promising Materials for Tumor Theranostics

doi:10.1021/acsbiomaterials.0c01058

	Photodynamic Nanophotosensitizers: Promising Materials for Tumor Theranostics
	Keerthiga, Rajendiran 2; Zhao, Zizhen 2; Pei, Desheng 1; Fu, Ailing 2
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2020-10-01
卷号	6 期号:10 页码:5474-5485
关键词	photodynamic therapy photosensitizer oncological therapeutics nanocarriers reactive oxygen species upconversion nanoparticles
ISSN号	2373-9878
DOI	10.1021/acsbiomaterials.0c01058
通讯作者	Pei, Desheng(peids@cigit.ac.cn) ; Fu, Ailing(fal@swu.edu.cn)
英文摘要	Photodynamic theranostics/therapy (PDT) is a potential strategy for selectively imaging malignant sites and treating cancer via a non-invasive therapeutic method. Photosensitizers, the crucial components of PDT, enable colocalization of photons and light, and photon/light therapy in the therapeutic window of 400-900 nm exhibits photocytotoxicity to tumor cells. Due to their high biostability and photocytotoxicity, nanophotosensitizers (NPSs) are of much interest for malignant tumor theranostics at present. NPS-activated photons transfer energy through the absorption of a photon and convert molecular oxygen to the singlet reactive oxygen species, which leads to apoptosis and necrosis. Moreover, NPSs modified by polymers, including PLGA, PEG-PLA, PDLLA, PVCL-g-PLA, and P(VCL-co-VIM)-g-PLA, exhibit excellent biocompatibility, and a tumor-targeting molecule linked on the nanoparticle surface can precisely deliver NPSs into the tumor region. The development of NPSs will accelerate the progress in tumor theranostics through the photon/light pathway.
资助项目	Chongqing Research Program of Basic Research and Frontier Technology[cstc2018jcy-jAX0612] ; Chongqing Innovation Project for Returnees from Overseas Scholars in 2018[cx2018086] ; Chongqing Key Program of Basic Research and Advanced Exploration Project[cstc2019jcyj-zdxm0092]
WOS研究方向	Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000580903800007
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/12279]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Pei, Desheng; Fu, Ailing
作者单位	1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 2.Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China
推荐引用方式 GB/T 7714	Keerthiga, Rajendiran,Zhao, Zizhen,Pei, Desheng,et al. Photodynamic Nanophotosensitizers: Promising Materials for Tumor Theranostics[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(10):5474-5485.
APA	Keerthiga, Rajendiran,Zhao, Zizhen,Pei, Desheng,&Fu, Ailing.(2020).Photodynamic Nanophotosensitizers: Promising Materials for Tumor Theranostics.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(10),5474-5485.
MLA	Keerthiga, Rajendiran,et al."Photodynamic Nanophotosensitizers: Promising Materials for Tumor Theranostics".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.10(2020):5474-5485.