Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA

doi:10.1039/d0cc02522d

	Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA
	Peng, Haibo 2; Xie, Beibei 2; Yang, Xiaohong 1; Dai, Jiaojiao 2; Wei, Guoxing 2; He, Yun 2
刊名	CHEMICAL COMMUNICATIONS
	2020-07-25
卷号	56 期号:58 页码:8115-8118
ISSN号	1359-7345
DOI	10.1039/d0cc02522d
通讯作者	He, Yun(yun.he@cqu.edu.cn)
英文摘要	A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), which target macrophages, respond to both acid and cathepsin B, and release vancomycin (Van) rapidly inside macrophages. Man@AP5-Van significantly increases the intracellular concentration of Van, enhancing its antibacterial efficacy against intracellular MRSA.
资助项目	National Nature Science Foundation of China[21572027] ; Chongqing Science and Technology Bureau[csts2019jcyj-zdxmX0021] ; Chongqing Postdoctoral Science Special Foundation[XmT2019023]
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000550563800023
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/11299]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	He, Yun
作者单位	1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, 266 Fangzheng Ave, Chongqing 400714, Peoples R China 2.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, 55 Daxuecheng South Rd, Chongqing 401331, Peoples R China
推荐引用方式 GB/T 7714	Peng, Haibo,Xie, Beibei,Yang, Xiaohong,et al. Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA[J]. CHEMICAL COMMUNICATIONS,2020,56(58):8115-8118.
APA	Peng, Haibo,Xie, Beibei,Yang, Xiaohong,Dai, Jiaojiao,Wei, Guoxing,&He, Yun.(2020).Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA.CHEMICAL COMMUNICATIONS,56(58),8115-8118.
MLA	Peng, Haibo,et al."Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA".CHEMICAL COMMUNICATIONS 56.58(2020):8115-8118.