Individual and combined toxicogenetic effects of microplastics and heavy metals (Cd, Pb, and Zn) perturb gut microbiota homeostasis and gonadal development in marine medaka (Oryzias melastigma)

doi:10.1016/j.jhazmat.2020.122795

	Individual and combined toxicogenetic effects of microplastics and heavy metals (Cd, Pb, and Zn) perturb gut microbiota homeostasis and gonadal development in marine medaka (Oryzias melastigma)
	Yan, Wang 1,3; Hamid, Naima 1,3; Deng, Shun 1,3; Jia, Pan-Pan 1,3; Pei, De-Sheng 1,2,3
刊名	JOURNAL OF HAZARDOUS MATERIALS
	2020-10-05
卷号	397 页码:11
关键词	Heavy metal Polystyrene microplastic Microflora HPG axis
ISSN号	0304-3894
DOI	10.1016/j.jhazmat.2020.122795
通讯作者	Pei, De-Sheng(peids@cigit.ac.cn)
英文摘要	Currently, microplastics (MPs) attracted increased attention for their ubiquity and toxic properties. In this study, marine medaka was used to explore the individual and combined toxicity of heavy metals (HMs) and MPs on intestinal bacteria and gonadal development. After exposure to environmentally relevant concentrations of MPs and HMs, significant alterations of intestinal microbiota were found. The MPs treatment reduced the diversity and abundance of intestinal microbiota, while the HMs and MPs-HMs treatments increased them, which were confirmed by the abundance changes of Proteobacteria. According to the KEGG analysis, the metabolism and environmental information processing (EIP) pathways in the microbial community were significantly affected. This study showed that the MPs-HMs treatment caused a higher pollution load on the gut of the marine medaka, and triggered more significant changes of specific bacterial species and gut function in the males. However, during the gonadal development, HMs and MPs-HMs treatments resulted in empty follicles (EF) and follicular atresia (FA), and altered the gene expression levels related to hypothalamic-pituitary-gonadal (HPG) axis. In short, this study demonstrated that the reproductive disturbance was mainly due to HMs, but the combination of MPs and HMs did not strengthen the risk to the gonad development of the marine medaka.
资助项目	CAS Team Project of the Belt and Road ; Chongqing Key Program of Basic Research and Advanced Exploration Project[cstc2019jcyj-zdxmX0035] ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; CAS-TWAS Scholarship[2017A8018537001] ; Program of China-Sri Lanka Joint Research and Demonstration Center for Water Technology and China-Sri Lanka Joint Center for Education and Research by Chinese Academy of Sciences, China
WOS研究方向	Engineering ; Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000541927100063
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/11255]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Pei, De-Sheng
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China 3.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Key Lab Reservoir Aquat Environm, Chongqing 400714, Peoples R China
推荐引用方式 GB/T 7714	Yan, Wang,Hamid, Naima,Deng, Shun,et al. Individual and combined toxicogenetic effects of microplastics and heavy metals (Cd, Pb, and Zn) perturb gut microbiota homeostasis and gonadal development in marine medaka (Oryzias melastigma)[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,397:11.
APA	Yan, Wang,Hamid, Naima,Deng, Shun,Jia, Pan-Pan,&Pei, De-Sheng.(2020).Individual and combined toxicogenetic effects of microplastics and heavy metals (Cd, Pb, and Zn) perturb gut microbiota homeostasis and gonadal development in marine medaka (Oryzias melastigma).JOURNAL OF HAZARDOUS MATERIALS,397,11.
MLA	Yan, Wang,et al."Individual and combined toxicogenetic effects of microplastics and heavy metals (Cd, Pb, and Zn) perturb gut microbiota homeostasis and gonadal development in marine medaka (Oryzias melastigma)".JOURNAL OF HAZARDOUS MATERIALS 397(2020):11.