Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118

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	Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118
	Shang Zhuo 2,3; Li Xiaoming 3; Meng Li1 ; Li Chunshun 3; Gao Shushan 2,3; Huang Caiguo 1; Wang Bingui3
刊名	CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
	2012-03-01
卷号	30 期号:2 页码:305-314
关键词	bioguided isolation deep-sea sediment-derived fungus Penicillium commune xanthocillin X antibacterial activity cytotoxicity
ISSN号	0254-4059
通讯作者	Huang, CG (reprint author), Mil Med Coll 2, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China.
英文摘要	Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118, a fungus obtained from a deep-sea sediment sample, resulted in the isolation of a known antibacterial compound, xanthocillin X (1), and 14 other known compounds comprising three steroids (2-4), two ceramides (5 and 6), six aromatic compounds (7-12), and three alkaloids (13-15). Xanthocillin X (1) was isolated for the first time from a marine fungus. In the bioassay, xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli, and significant cytotoxicity against MCF-7, HepG2, H460, Hela, Du145, and MDA-MB-231 cell lines. Meleagrin (15) exhibited cytotoxicity against HepG2, Hela, Du145, and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X (1).
学科主题	Limnology ; Oceanography
收录类别	SCI
原文出处	10.1007/s00343-012-1075-1
语种	英语
WOS记录号	WOS:000301001900015
公开日期	2013-09-25
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/12528]
专题	海洋研究所_海洋生物分类与系统演化实验室海洋研究所_实验海洋生物学重点实验室
作者单位	1.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Shang Zhuo,Li Xiaoming,Meng Li,et al. Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2012,30(2):305-314.
APA	Shang Zhuo.,Li Xiaoming.,Meng Li.,Li Chunshun.,Gao Shushan.,...&Wang Bingui.(2012).Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,30(2),305-314.
MLA	Shang Zhuo,et al."Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 30.2(2012):305-314.