A learning based framework for diverse biomolecule relationship prediction in molecular association network

doi:10.1038/s42003-020-0858-8

CORC > 新疆理化技术研究所 > 中国科学院新疆理化技术研究所 > 多语种信息技术研究室

	A learning based framework for diverse biomolecule relationship prediction in molecular association network
	Guo, ZH (Guo, Zhen-Hao)[ 1,2 ]; You, ZH (You, Zhu-Hong)[ 1,2 ]; Huang, DS (Huang, De-Shuang)[ 3 ]; Yi, HC (Yi, Hai-Cheng)[ 1,2 ]; Chen, ZH (Chen, Zhan-Heng)[ 1,2 ]; Wang, YB (Wang, Yan-Bin)[ 4 ]
刊名	COMMUNICATIONS BIOLOGY
	2020
卷号	3 期号:1 页码:1-9
ISSN号	2399-3642
DOI	10.1038/s42003-020-0858-8
英文摘要	Abundant life activities are maintained by various biomolecule relationships in human cells. However, many previous computational models only focus on isolated objects, without considering that cell is a complete entity with ample functions. Inspired by holism, we constructed a Molecular Associations Network (MAN) including 9 kinds of relationships among 5 types of biomolecules, and a prediction model called MAN-GF. More specifically, biomolecules can be represented as vectors by the algorithm called biomarker2vec which combines 2 kinds of information involved the attribute learned by k-mer, etc and the behavior learned by Graph Factorization (GF). Then, Random Forest classifier is applied for training, validation and test. MAN-GF obtained a substantial performance with AUC of 0.9647 and AUPR of 0.9521 under 5-fold Cross-validation. The results imply that MAN-GF with an overall perspective can act as ancillary for practice. Besides, it holds great hope to provide a new insight to elucidate the regulatory mechanisms.
WOS记录号	WOS:000521060500004
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/7288]
专题	新疆理化技术研究所_多语种信息技术研究室
通讯作者	You, ZH (You, Zhu-Hong)[ 1,2 ]
作者单位	1.Zhejiang Univ, Sch Cyber Sci & Technol, Hangzhou 310000, Zhejiang, Peoples R China 2.Tongji Univ, Dept Comp Sci, Shanghai 200000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
推荐引用方式 GB/T 7714	Guo, ZH ,You, ZH ,Huang, DS ,et al. A learning based framework for diverse biomolecule relationship prediction in molecular association network[J]. COMMUNICATIONS BIOLOGY,2020,3(1):1-9.
APA	Guo, ZH ,You, ZH ,Huang, DS ,Yi, HC ,Chen, ZH ,&Wang, YB .(2020).A learning based framework for diverse biomolecule relationship prediction in molecular association network.COMMUNICATIONS BIOLOGY,3(1),1-9.
MLA	Guo, ZH ,et al."A learning based framework for diverse biomolecule relationship prediction in molecular association network".COMMUNICATIONS BIOLOGY 3.1(2020):1-9.