Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus | |
Obul, M (Obul, Mamateli)[ 1,2 ]; Wang, XC (Wang, Xincheng)[ 1,2 ]; Zhao, JY (Zhao, Jiangyu)[ 1 ]; Li, G (Li, Gen)[ 1 ]; Aisa, HA (Aisa, Haji Akber)[ 1 ]; Huang, GZ (Huang, Guozheng)[ 1 ] | |
刊名 | MOLECULAR DIVERSITY
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2019 | |
卷号 | 23期号:1页码:1-9 |
关键词 | Rupestonic acidInfluenza virusArtemisia rupestrisBenzylation |
ISSN号 | 1381-1991 |
DOI | 10.1007/s11030-018-9840-5 |
英文摘要 | Influenza viruses are responsible for seasonal epidemics and occasional pandemics, which cause significant morbidity and mortality. Although several drugs (adamantanes and neuraminidase inhibitors) are available in the market, the worldwide spread of drug-resistant influenza strains poses an urgent need for novel antiviral drugs. Artemisia rupestris L. is a folk medicine used to treat cold. In this paper, we structurally modified rupestonic acid, a bioactive component of A. rupestris, to synthesize a series of 2-substituted rupestonic acid methyl esters (3a-3o). Their structures were fully characterized by H-1 NMR, C-13 NMR, HRMS spectra. Among them, compounds 3b and 3c exhibited potent activities against influenza H1N1 with micromolar IC50 values and might serve as new lead compounds for the treatment of influenza. |
WOS记录号 | WOS:000459517700001 |
内容类型 | 期刊论文 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/7852] ![]() |
专题 | 新疆理化技术研究所_资源化学研究室 |
通讯作者 | Aisa, HA (Aisa, Haji Akber)[ 1 ] |
作者单位 | 1.Univ Chinese Acad Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, State Key Lab Basis Xinjiang Indigenous Med Plant, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China |
推荐引用方式 GB/T 7714 | Obul, M ,Wang, XC ,Zhao, JY ,et al. Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus[J]. MOLECULAR DIVERSITY,2019,23(1):1-9. |
APA | Obul, M ,Wang, XC ,Zhao, JY ,Li, G ,Aisa, HA ,&Huang, GZ .(2019).Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus.MOLECULAR DIVERSITY,23(1),1-9. |
MLA | Obul, M ,et al."Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus".MOLECULAR DIVERSITY 23.1(2019):1-9. |
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