Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam | |
Zhao, YX (Zhao, Yongxin); Dou, J (Dou, Jun); Wu, T (Wu, Tao); Aisa, HA (Aisa, Haji Akber) | |
刊名 | MOLECULES
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2013 | |
卷号 | 18期号:1页码:951-962 |
关键词 | Gossypium Herbaceam Antioxidant Activity Alzheimer’s Disease Flavonoid |
ISSN号 | 1466-8033 |
DOI | 10.3390/molecules18010951 |
英文摘要 | Our previous research showed that standardized extract from the flowers of the Gossypium herbaceam labeled GHE had been used in clinical trials for its beneficial effects on brain functions, particularly in connection with age-related dementia and Alzheimer's disease (AD). The aim of this work was to determine the components of this herb and the individual constituents of GHE. In order to better understand this herb for AD treatment, we investigated the acetylcholinesterase (AChE) inhibition and antioxidant activity of GHE as well as the protective effects to PC12 cells against cytotoxicity induced by tertiary butyl hydroperoxide (tBHP) using in vitro assays. The antioxidant activities were assessed by measuring their capabilities for scavenging 1,1-diphenyl-2-picylhydrazyl (DPPH) and 2-2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical as well as in inhibiting lipid peroxidation. Our data showed that GHE exhibited certain activities against AChE and also is an efficient free radical scavenger, which may be helpful in preventing or alleviating patients suffering from AD. |
学科主题 | Chemistry |
WOS记录号 | WOS:000314032900059 |
公开日期 | 2013-05-21 |
内容类型 | 期刊论文 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/2446] ![]() |
专题 | 新疆理化技术研究所_资源化学研究室 |
通讯作者 | Aisa, HA (Aisa, Haji Akber) |
作者单位 | Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, YX ,Dou, J ,Wu, T ,et al. Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam[J]. MOLECULES,2013,18(1):951-962. |
APA | Zhao, YX ,Dou, J ,Wu, T ,&Aisa, HA .(2013).Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam.MOLECULES,18(1),951-962. |
MLA | Zhao, YX ,et al."Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam".MOLECULES 18.1(2013):951-962. |
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