Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai

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	Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai
	Liang, Yi; Li, Xiao-Ming; Cui, Chuan-Ming; Li, Chun-Shun; Sun, Hong; Wang, Bin-Gui
刊名	MARINE DRUGS
	2012-12-01
卷号	10 期号:12 页码:2817-2825
关键词	marine alga Laurencia okamurai bisabolane sesquiterpene C-12-acetogenin brine shrimp lethality
ISSN号	1660-3397
通讯作者	Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China.
英文摘要	In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A-D (1-4), a new chamigrane derivative, okamurene E (5), and a new C-12-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C-12-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD50 1.8 mu M.
学科主题	Chemistry, Medicinal
收录类别	SCI
原文出处	10.3390/md10122817
语种	英语
WOS记录号	WOS:000312607700015
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/12381]
专题	海洋研究所_实验海洋生物学重点实验室海洋研究所_胶州湾海洋生态系统国家野外研究站
作者单位	Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Liang, Yi,Li, Xiao-Ming,Cui, Chuan-Ming,et al. Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai[J]. MARINE DRUGS,2012,10(12):2817-2825.
APA	Liang, Yi,Li, Xiao-Ming,Cui, Chuan-Ming,Li, Chun-Shun,Sun, Hong,&Wang, Bin-Gui.(2012).Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai.MARINE DRUGS,10(12),2817-2825.
MLA	Liang, Yi,et al."Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai".MARINE DRUGS 10.12(2012):2817-2825.