Guaianolide sesquiterpene lactones from Achillea millefolium L

doi:10.1016/j.phytochem.2021.112733

	Guaianolide sesquiterpene lactones from Achillea millefolium L
	Li, Hongliang 1,2,4; Li, Jun 1,2; Liu, Mengqi 3,4; Xie, Rongrong 3; Zang, Yi 3,4; Li, Jia 3,4,5; Aisa, Haji Akber 1,2
刊名	PHYTOCHEMISTRY
	2021-06-01
卷号	186 页码:9
关键词	Achillea millefolium L. Asteraceae Guaianolide sesquiterpene lactones Millefoliumins A-G Melaogenesis Anti-inflammatory
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2021.112733
通讯作者	Li, Jia(jli@simm.ac.cn) ; Aisa, Haji Akber(haji@ms.xjb.ac.cn)
英文摘要	Seven undescribed guaianolide sesquiterpene lactones, millefoliumins A-G, and five known analogues were isolated from the whole plant of Achillea millefolium L. growing in Xinjiang, China. Their structures were elucidated by analysis of spectroscopic data and comparison with literatures. The absolute configurations of millefoliumins A-G were determined by single-crystal X-ray crystallography, ECD data analysis along with quantum-chemical ECD calculations. The X-ray crystal structures of 8 alpha-angeloxy-1 beta,2 beta,4 beta,5 beta-diepoxy-10 beta-hydroxy-6 beta H,7 alpha H,11 beta H-12,6 alpha-guaianolide and 8 alpha-angeloxy-4 alpha,10 beta-dihydroxy-2-oxo-6 beta H,7 alpha H,11 beta H-1(5)-guaien-12,6 alpha-olide were reported for the first time, and the full C-13 NMR data of malaphyllidin were attributed for the first time. Millefoliumins F and G, and austricin could improve the melaogenesis by increasing the melanin content and tyrosinase activity of B16 melanoma cells. Millefoliumins A, C and D, and austricin showed anti-inflammatory activity against the NO production in LPS-induced RAW264.7 cells.
资助项目	National Natural Science Foundation of China[U1703235] ; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization[2017D04016] ; National Science & Technology Major Project Key New Drug Creation and Maufacturing Program[2019ZX09201001-003-001] ; National Science & Technology Major Project Key New Drug Creation and Maufacturing Program[2019ZX09201001-003-010]
WOS关键词	ANTIINFLAMMATORY ACTIVITY ; FLAVONOIDS ; MEDICINE ; EXTRACT ; FLOWER ; YARROW ; PLANTS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000644703200015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296606]
专题	中国科学院上海药物研究所
通讯作者	Li, Jia; Aisa, Haji Akber
作者单位	1.Chinese Acad Sci, State Key Lab Basis Xinjiang Indigenous Med Plant, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China 2.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 10049, Peoples R China 5.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Li, Hongliang,Li, Jun,Liu, Mengqi,et al. Guaianolide sesquiterpene lactones from Achillea millefolium L[J]. PHYTOCHEMISTRY,2021,186:9.
APA	Li, Hongliang.,Li, Jun.,Liu, Mengqi.,Xie, Rongrong.,Zang, Yi.,...&Aisa, Haji Akber.(2021).Guaianolide sesquiterpene lactones from Achillea millefolium L.PHYTOCHEMISTRY,186,9.
MLA	Li, Hongliang,et al."Guaianolide sesquiterpene lactones from Achillea millefolium L".PHYTOCHEMISTRY 186(2021):9.