Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage

doi:10.1016/j.intimp.2021.107482

	Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage
	Wu, Bing 1,2; Wu, Yanwei 1; Fan, Chen 1; Feng, Chunlan 1; Wang, Haoyu 1,2; Bai, Fang 1,2; Zuo, Jianping 2,3; Tang, Wei 1,2
刊名	INTERNATIONAL IMMUNOPHARMACOLOGY
	2021-05-01
卷号	94 页码:11
关键词	SLE Lupus nephritis Heme Inflammation Oxidative damage
ISSN号	1567-5769
DOI	10.1016/j.intimp.2021.107482
通讯作者	Zuo, Jianping(jpzuo@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn)
英文摘要	Heme is an important iron-containing porphyrin molecule expressed ubiquitously in organisms. Recently, this endogenous molecule has been widely reported to be involved in the pathogenesis of numerous diseases such as sepsis, atherosclerosis and inflammatory bowel disease. However, the role of heme during systemic lupus erythematosus (SLE) pathogenesis has not been previously evaluated. Herein, we have measured the levels of heme in lupus-prone mice and explored the influence of heme on the pathogenesis of lupus. We revealed that heme levels in serum, kidney and spleen lymphocytes are all negatively associated with the levels of proteinuria in lupus-prone mice. Heme supplementation at 15 mg/kg could significantly ameliorate the syndromes of lupus in MRL/lpr mice, extending lifespan, reducing the level of proteinuria and alleviating splenomegaly and lymphadenopathy. Further study demonstrated that heme replenishment corrected the abnormal compartment of T cell subsets, plasma cells and macrophages in the spleen and alleviates inflammation and oxidative damage in kidney of MRL/lpr mice. Our study well defined heme as a relevant endogenous molecule in the etiology of SLE, as well as a potential therapeutic target for treating this autoimmune disease. Meanwhile, heme replenishment might be a new choice to therapeutically modulate immune homeostasis and prevent SLE.
资助项目	National Natural Science Foundation of China[81673445] ; National Natural Science Foundation of China[81803543] ; Shanghai Committee of Science and Technology, China[18431901200] ; Shanghai Committee of Science and Technology, China[18431907100] ; national Science & Technology Major Project New Drug Creation and Manufacturing Program, China[2017ZX09101002-002-010]
WOS关键词	ERYTHEMATOSUS ; OXYGENASE ; MACROPHAGES ; EXPRESSION ; INDUCTION ; MODEL ; CELL
WOS研究方向	Immunology ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000644429000004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296512]
专题	中国科学院上海药物研究所
通讯作者	Zuo, Jianping; Tang, Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Wu, Bing,Wu, Yanwei,Fan, Chen,et al. Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2021,94:11.
APA	Wu, Bing.,Wu, Yanwei.,Fan, Chen.,Feng, Chunlan.,Wang, Haoyu.,...&Tang, Wei.(2021).Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage.INTERNATIONAL IMMUNOPHARMACOLOGY,94,11.
MLA	Wu, Bing,et al."Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage".INTERNATIONAL IMMUNOPHARMACOLOGY 94(2021):11.