What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design

doi:10.1002/med.21783

	What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design
	Xiong, Muya 2,3; Su, Haixia 2,3; Zhao, Wenfeng 2; Xie, Hang 2; Shao, Qiang 2,3; Xu, Yechun 1,2,3
刊名	MEDICINAL RESEARCH REVIEWS
	2021-01-18
页码	34
关键词	3C-like protease binding modes coronavirus inhibitors structure and function
ISSN号	0198-6325
DOI	10.1002/med.21783
通讯作者	Shao, Qiang(qshao@simm.ac.cn) ; Xu, Yechun(ycxu@simm.ac.cn)
英文摘要	The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to more than 70 million infections and over 1.6 million of deaths worldwide in the past few months. None of the efficacious antiviral agents against human CoVs have been approved yet. 3C-like protease (3CL(pro)) is an attractive target for antiviral intervention due to its essential role in processing polyproteins translated from viral RNA, and its conserved structural feature and substrate specificity among CoVs in spite of the sequence variation. This review focuses on all available crystal structures of 12 CoV 3CL(pro)s and their inhibitors, and intends to provide a comprehensive understanding of this protease from multiple aspects including its structural features, substrate specificity, inhibitor binding modes, and more importantly, to recapitulate the similarity and diversity among different CoV 3CL(pro)s and the structure-activity relationship of various types of inhibitors. Such an attempt could gain a deep insight into the inhibition mechanisms and drive future structure-based drug discovery targeting 3CL(pro)s.
资助项目	Science and Technology Commission of Shanghai Municipality[20430780300] ; National Natural Science Foundation of China[21877122] ; National Natural Science Foundation of China[32071248]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000608316400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296114]
专题	中国科学院上海药物研究所
通讯作者	Shao, Qiang; Xu, Yechun
作者单位	1.Univ Chinese Acad Sci, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xiong, Muya,Su, Haixia,Zhao, Wenfeng,et al. What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design[J]. MEDICINAL RESEARCH REVIEWS,2021:34.
APA	Xiong, Muya,Su, Haixia,Zhao, Wenfeng,Xie, Hang,Shao, Qiang,&Xu, Yechun.(2021).What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design.MEDICINAL RESEARCH REVIEWS,34.
MLA	Xiong, Muya,et al."What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design".MEDICINAL RESEARCH REVIEWS (2021):34.