Two new flavonoid glycosides isolated from the fruits of Catalpa ovata

doi:10.4103/pm.pm_91_20

	Two new flavonoid glycosides isolated from the fruits of Catalpa ovata
	Zhang, Liu-Qiang 1; Xue, Hai-Bing 1; Zhu, Wei-Liang 2; Li, Yi-Ming 1; Chen, Kai-Xian 1,2
刊名	PHARMACOGNOSY MAGAZINE
	2020-10-01
卷号	16 期号:72 页码:812-816
关键词	Antioxidant activity Catalpa ovata flavonoid glycosides polyphenols structure– activity relationship
ISSN号	0973-1296
DOI	10.4103/pm.pm_91_20
通讯作者	Li, Yi-Ming(ymli@shutcm.edu.cn) ; Chen, Kai-Xian(kxchen@simm.ac.cn)
英文摘要	Background: Catalpa ovata, widespread in China, Japan, and Korea, is receiving greater attention due to its potent pharmacological properties. Objectives: This communication report presents the results of chemical investigation and antioxidant capacity of the fruits of C. ovata. Materials and Methods: The polar fraction from the fruits of C. ovata was isolated using various chromatographic methods and their structures were identified through nuclear magnetic resonance spectrometry and high-resolution mass spectrometry, and the data were compared with the reported literature. Total antioxidant activity was analyzed using the total antioxidant capacity assay kit with a rapid ABTS method. Results: Cavonosides A and B (1 and 2), two new flavonoid glycosides, together with 13 known phenols (3-15), were obtained from the fruits of C. ovata. The antioxidant capacity of compounds 4, 7, 10, 13, and 15 was approximately equal to that of Vitamin C at the same concentration. Conclusion: This research work resulted in two new flavonoid glycosides (1 and 2) and 13 known phenols isolated from the fruits of C. ovata; among them, compounds 4, 7-10, and 13 were newly isolated from this genus. According to our results, the antioxidant capacity of compounds 4, 7, 10, 13 and 15 was approximately same as that of Vitamin C at the same concentration. We also discuss the structure-activity relationships of the isolated compounds.
资助项目	Shanghai Science and Technology Innovation action plan[18401931100] ; National Natural Science Foundation of China[81973458] ; Drug Innovation Major Project[2018ZX09711001-005-022]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	WOLTERS KLUWER MEDKNOW PUBLICATIONS
WOS记录号	WOS:000621667300019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295833]
专题	中国科学院上海药物研究所
通讯作者	Li, Yi-Ming; Chen, Kai-Xian
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept Tradit Chinese Med Chem, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Liu-Qiang,Xue, Hai-Bing,Zhu, Wei-Liang,et al. Two new flavonoid glycosides isolated from the fruits of Catalpa ovata[J]. PHARMACOGNOSY MAGAZINE,2020,16(72):812-816.
APA	Zhang, Liu-Qiang,Xue, Hai-Bing,Zhu, Wei-Liang,Li, Yi-Ming,&Chen, Kai-Xian.(2020).Two new flavonoid glycosides isolated from the fruits of Catalpa ovata.PHARMACOGNOSY MAGAZINE,16(72),812-816.
MLA	Zhang, Liu-Qiang,et al."Two new flavonoid glycosides isolated from the fruits of Catalpa ovata".PHARMACOGNOSY MAGAZINE 16.72(2020):812-816.