Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation1

	Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation1
	Linghua MENG; Jian DING
刊名	Acta Pharmacologica Sinica
	2007
卷号	28 期号:9 页码:1460
关键词	salvicine topoisomerase II ROS DNA damage multidrug-resisitant antimetastasis
ISSN号	1671-4083
英文摘要	Salvicine is a novel diterpenoid quinone compound obtained by structural modification of a natural product lead isolated from a Chinese herb with potent growth inhibitory activity against a wide spectrum of human tumor cells in vitro and in mice bearing human tumor xenografts. Salvicine has also been found to have a profound cytotoxic effect on multidrug-resisitant (MDR) cells. Moreover, Salvicine significantly reduced the lung metastatic foci of MDA-MB-435 orthotopic xenograft. Recent studies demonstrated that salvicine is a novel non-intercalative topoisomerase II (Topo II) poison by binding to the ATPase domain, promoting DNA-Topo II binding and inhibiting Topo II-mediated DNA relegation and ATP hydrolysis. Further studies have indicated that salcivine-elicited ROS plays a central role in salvicine-induced cellular response including Topo II inhibition, DNA damage, circumventing MDR and tumor cell adhesion inhibition.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/294918]
专题	中国科学院上海药物研究所
作者单位	中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Linghua MENG,Jian DING. Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation1[J]. Acta Pharmacologica Sinica,2007,28(9):1460.
APA	Linghua MENG,&Jian DING.(2007).Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation1.Acta Pharmacologica Sinica,28(9),1460.
MLA	Linghua MENG,et al."Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation1".Acta Pharmacologica Sinica 28.9(2007):1460.