Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells

	Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells
	Qinghao Jin 3; Jianqing Zhang 3; Jinjun Hou 3; Min Lei 3; Chen Liu 3; Xia Wang 3; Yong Huang 3; Shuai Yao 3; Bang Yeon Hwang 2; Wanying Wu 3
刊名	药学学报:英文版
	2019
卷号	000 期号:004 页码:809
关键词	Alisma plantago-aquatica Linn. Protostane-type triterpenoids Caco-2 cells LPS-induced NO production
ISSN号	2211-3835
英文摘要	Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds(1 e9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A-F(1 e6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H(8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I(9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4-6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76 e38.20 mmol/L.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/293205]
专题	中国科学院上海药物研究所
作者单位	1.School of Pharmacy,Shenyang Pharmaceutical University 2.College of Pharmacy,Chungbuk National University,South Korea 3.中国科学院上海药物研究所 4.中国科学院大学
推荐引用方式 GB/T 7714	Qinghao Jin,Jianqing Zhang,Jinjun Hou,et al. Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells[J]. 药学学报:英文版,2019,000(004):809.
APA	Qinghao Jin.,Jianqing Zhang.,Jinjun Hou.,Min Lei.,Chen Liu.,...&Dean Guo.(2019).Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells.药学学报:英文版,000(004),809.
MLA	Qinghao Jin,et al."Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells".药学学报:英文版 000.004(2019):809.