Structurally diverse halosesquiterpenoids from the red alga Laurencia composita Yamada

doi:10.1016/j.fitote.2020.104716

	Structurally diverse halosesquiterpenoids from the red alga Laurencia composita Yamada
	Hu, Zhi-Biao 1; Yu, Xiao-Qing 1; Wang, Bin 1; Liu, Ai-Hong 2; Zhao, Tian-Sheng 1; Guo, Yue-Wei 3; Huang, Hui-Lian 4; Mao, Shui-Chun 1
刊名	FITOTERAPIA
	2020-10-01
卷号	146 页码:9
关键词	Laurencia composita Chamigrane sesquiterpenoids Bisabolane sesquiterpenoids Nerolidol derivative Modified Mosher's method Antifungal activity Antibacterial activity
ISSN号	0367-326X
DOI	10.1016/j.fitote.2020.104716
通讯作者	Mao, Shui-Chun(maoshuichun@ncu.edu.cn)
英文摘要	A phytochemical investigation on the MeOH extract of the red alga Laurencia composita Yamada led to the discovery of six new highly halogenated sesquiterpenoids, including two bisabolane-type sesquiterpenoids (1 and 2), one nerolidol derivative (7), and three chamigrane-type sesquiterpenoids (9, 10, and 18), together with 13 known sesquiterpenoids. Their structures, including relative configuration, were elucidated by extensive spectroscopic analysis, and by comparison with data for related known compounds. The absolute configuration at C-10 of laurecomposin A (1) was determined by the modified Mosher's method. Halonerolidol (7) is the first naturally occurring halogenated nerolidol derivative, while compositacin L (9) represents the third example of chamigranes having a C-10 carbonyl group. Antifungal, antibacterial, and receptor tyrosine kinase inhibitory activities of these isolates were evaluated. The results showed that compounds 1-3 and 5 exhibited significant antifungal activity against Microsporum gypseum (Cmccfmza) with MIC values of 4, 8, 8, and 4 mu g/mL, respectively. Additionally, compounds 1-3 and 5 also displayed promising antibacterial activity against Gram-positive bacteria Staphylococcus aureus Newman strain with MIC values ranging from 10.9 to 26.8 mu g/mL.
资助项目	National Natural Science Foundation of China[21362024] ; National Natural Science Foundation of China[81860616] ; Natural Science Foundation of Jiangxi Province, China[20151BAB205082] ; Natural Science Foundation of Jiangxi Province, China[20161BAB205211] ; Natural Science Foundation of Jiangxi Province, China[20181BAB205086] ; State Key Laboratory of Drug Research-SIMM[SIMM1803KF-01]
WOS关键词	ABSOLUTE-CONFIGURATIONS ; CHAMIGRENE DERIVATIVES ; LAURANE SESQUITERPENE ; CONSTITUENTS ; CHEMISTRY ; PRODUCTS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000580427700062
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292533]
专题	中国科学院上海药物研究所
通讯作者	Mao, Shui-Chun
作者单位	1.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China 2.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Jiangxi, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Jiangxi Univ Tradit Chinese Med, Coll Pharm, Nanchang 330004, Jiangxi, Peoples R China
推荐引用方式 GB/T 7714	Hu, Zhi-Biao,Yu, Xiao-Qing,Wang, Bin,et al. Structurally diverse halosesquiterpenoids from the red alga Laurencia composita Yamada[J]. FITOTERAPIA,2020,146:9.
APA	Hu, Zhi-Biao.,Yu, Xiao-Qing.,Wang, Bin.,Liu, Ai-Hong.,Zhao, Tian-Sheng.,...&Mao, Shui-Chun.(2020).Structurally diverse halosesquiterpenoids from the red alga Laurencia composita Yamada.FITOTERAPIA,146,9.
MLA	Hu, Zhi-Biao,et al."Structurally diverse halosesquiterpenoids from the red alga Laurencia composita Yamada".FITOTERAPIA 146(2020):9.