Dependence of PINK1 accumulation on mitochondrial redox system

doi:10.1111/acel.13211

	Dependence of PINK1 accumulation on mitochondrial redox system
	Gao, Feng 1,2,3; Zhang, Yan 1,2; Hou, Xiaoou 1,2; Tao, Zhouteng 1,2,4; Ren, Haigang 1,2; Wang, Guanghui 1,2
刊名	AGING CELL
	2020-08-11
页码	14
关键词	autophagy mitochondrion mitophagy neurodegenerative diseases PINK1
ISSN号	1474-9718
DOI	10.1111/acel.13211
通讯作者	Gao, Feng(fenggao7@ustc.edu.cn) ; Wang, Guanghui(wanggh@suda.edu.cn)
英文摘要	Accumulation of PINK1 on the outer mitochondrial membrane (OMM) is necessary for PINK-mediated mitophagy. The proton ionophores, like carbonyl cyanide m-chlorophenylhydrazone (CCCP) and carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP), inhibit PINK1 import into mitochondrial matrix and induce PINK1 OMM accumulation. Here, we show that the CHCHD4/GFER disulfide relay system in the mitochondrial intermembrane space (IMS) is required for PINK1 stabilization when mitochondrial membrane potential is lost. Activation of CHCHD4/GFER system by mitochondrial oxidative stress or inhibition of CHCHD4/GFER system with antioxidants can promote or suppress PINK1 accumulation, respectively. Thus data suggest a pivotal role of CHCHD4/GFER system in PINK1 accumulation. The amyotrophic lateral sclerosis-related superoxide dismutase 1 mutants dysregulated redox state and CHCHD4/GFER system in the IMS, leading to inhibitions of PINK1 accumulation and mitophagy. Thus, the redox system in the IMS is involved in PINK1 accumulation and damaged mitochondrial clearance, which may play roles in mitochondrial dysfunction-related neurodegenerative diseases.
资助项目	National Natural Sciences Foundation of China[81701255] ; National Natural Sciences Foundation of China[31871023] ; National Natural Sciences Foundation of China[31970966] ; National Key Plan for Scientific Research and Development of China[2016YFC1306000] ; National Key Plan for Scientific Research and Development of China[2016YFC1300500] ; Suzhou Clinical Research Center of Neurological Disease[Szzx201503] ; Priority Academic Program Development of Jiangsu Higher Education Institutions
WOS关键词	INTERMEMBRANE SPACE ; SUPEROXIDE-DISMUTASE ; PROTEIN IMPORT ; MITOPHAGY ; PARKIN ; SOD1 ; PHOSPHORYLATION ; RECRUITMENT ; UBIQUITIN ; DYSFUNCTION
WOS研究方向	Cell Biology ; Geriatrics & Gerontology
语种	英语
出版者	WILEY
WOS记录号	WOS:000557897600001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292278]
专题	中国科学院上海药物研究所
通讯作者	Gao, Feng; Wang, Guanghui
作者单位	1.Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Disorders, Lab Mol Neuropathol, Suzhou 215123, Jiangsu, Peoples R China 2.Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacol, Suzhou 215123, Jiangsu, Peoples R China 3.Univ Sci & Technol China, Neurodegenerat Disorder Res Ctr, Div Life Sci & Med, Hefei, Anhui, Peoples R China 4.Chinese Acad Sci, Ctr Drug Safety Evaluat & Res, State Key Lab New Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Gao, Feng,Zhang, Yan,Hou, Xiaoou,et al. Dependence of PINK1 accumulation on mitochondrial redox system[J]. AGING CELL,2020:14.
APA	Gao, Feng,Zhang, Yan,Hou, Xiaoou,Tao, Zhouteng,Ren, Haigang,&Wang, Guanghui.(2020).Dependence of PINK1 accumulation on mitochondrial redox system.AGING CELL,14.
MLA	Gao, Feng,et al."Dependence of PINK1 accumulation on mitochondrial redox system".AGING CELL (2020):14.