Folded or Degraded in Endoplasmic Reticulum

doi:10.1007/978-981-15-3266-5_12

	Folded or Degraded in Endoplasmic Reticulum
	Li, Chushu 1; Xia, Bingqing 2; Wang, Sheng 3; Xu, Jie 4
刊名	REGULATION OF CANCER IMMUNE CHECKPOINTS: MOLECULAR AND CELLULAR MECHANISMS AND THERAPY
	2020
卷号	1248 页码:265-294
关键词	Immune checkpoint proteins Endoplasmic reticulum Glycosylation ER chaperones ER enzymes Protein folding COPII Vesicle trafficking ER proteostasis ER quality control ER stress UPR ERAD ERLAD Immunotherapy
ISSN号	0065-2598
DOI	10.1007/978-981-15-3266-5_12
通讯作者	Xu, Jie(jie_xu@fudan.edu.cn)
英文摘要	In consistent with other membrane-bound and secretory proteins, immune checkpoint proteins go through a set of modifications in the endoplasmic reticulum (ER) to acquire their native functional structures before they function at their destinations. There are various ER-resident chaperones and enzymes synergistically regulate and catalyze the glycosylation, folding and transporting of proteins. The whole processing is under the surveillance of ER quality control system which allows the correctly folded proteins to exit from the ER with the help of coat proteinII(COPII) coated vesicles, while retains the rest of terminally misfolded ones in the ER and then eliminates them via ER-associated degradation (ERAD) or ER-to-lysosomes-associated degradation (ERLAD). The dysfunction of the ER causes ER stress which triggers unfolded protein response (UPR) to restore ER proteostasis. Unsolvable prolonged ER stress ultimately results in cell death. This chapter reviews the process that proteins undergo in the ER, and the glycosylation, folding and degradation of immune checkpoint proteins as well as the associated potential immunotherapies to date.
WOS关键词	PROTEIN-DISULFIDE-ISOMERASE ; ER MANNOSIDASE-I ; QUALITY-CONTROL ; MEMBRANE-PROTEINS ; SACCHAROMYCES-CEREVISIAE ; BINDING-SPECIFICITY ; GOLGI LOCALIZATION ; ANTITUMOR IMMUNITY ; STRUCTURAL BASIS ; N-GLYCOSYLATION
WOS研究方向	Oncology ; Immunology ; Research & Experimental Medicine
语种	英语
出版者	SPRINGER INTERNATIONAL PUBLISHING AG
WOS记录号	WOS:000554918800012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292218]
专题	中国科学院上海药物研究所
通讯作者	Xu, Jie
作者单位	1.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Fudan Univ, Inst Biomed Sci, 130 Dongan Rd, Shanghai 200032, Peoples R China 4.Fudan Univ, Zhongshan Xuhui Hosp, Inst Biomed Sci, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Li, Chushu,Xia, Bingqing,Wang, Sheng,et al. Folded or Degraded in Endoplasmic Reticulum[J]. REGULATION OF CANCER IMMUNE CHECKPOINTS: MOLECULAR AND CELLULAR MECHANISMS AND THERAPY,2020,1248:265-294.
APA	Li, Chushu,Xia, Bingqing,Wang, Sheng,&Xu, Jie.(2020).Folded or Degraded in Endoplasmic Reticulum.REGULATION OF CANCER IMMUNE CHECKPOINTS: MOLECULAR AND CELLULAR MECHANISMS AND THERAPY,1248,265-294.
MLA	Li, Chushu,et al."Folded or Degraded in Endoplasmic Reticulum".REGULATION OF CANCER IMMUNE CHECKPOINTS: MOLECULAR AND CELLULAR MECHANISMS AND THERAPY 1248(2020):265-294.