Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma

doi:10.7150/jca.45146

	Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma
	Feng, Qilin 2; Yao, Qingchun 1; Li, Bo 3; Xie, Yongsheng 2; Zhang, Hui 2; Xu, Zhijian 3; Lu, Kang 2; Hu, Ke 2; Cheng, Yao 2; Shi, Bingqing 2
刊名	JOURNAL OF CANCER
	2020
卷号	11 期号:16 页码:4907-4916
关键词	DCZ0801 multiple myeloma apoptosis cell cycle glycolysis
ISSN号	1837-9664
DOI	10.7150/jca.45146
通讯作者	You, Shanxi(Js_ysx@sina.com) ; Shi, Jumei(shijumei@tongji.edu.cn) ; Zhu, Weiliang(wlzhu@simm.ac.cn)
英文摘要	Multiple myeloma (MM) is a highly invasive and incurable plasma cell malignant disease with frequent recurrence. DCZ0801 is a natural compound synthesized from osalmide and pterostilbene and has few adverse effects. Here, we aimed to observe the therapeutic effects of DCZ0801 on myeloma cells and clarify the specific molecular mechanism underlying its anti-tumor activity. The Cell Counting Kit-8 assay, apoptosis detection, cell cycle analysis, western blot analysis, and tumor xenograft models were used to determine the effect of DCZ0801 treatment both in vivo and in vitro. We revealed that DCZ0801 treatment suppressed MM cell survival by inducing apoptosis and blocking the cell cycle at S phase. Deranged glycolysis and downregulated Akt/mTOR pathway may also be responsible for cell proliferation inhibition. Moreover, DCZ0801 treatment could remarkably reduce the tumor size in the xenograft mouse model. Therefore these findings indicate that DCZ0801 can be used as a novel therapeutic drug for patients suffering from multiple myeloma.
资助项目	National Natural Science Foundation of China[81670194] ; National Natural Science Foundation of China[81870158] ; National Natural Science Foundation of China[81900212] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002]
WOS关键词	PYRUVATE-KINASE ; CANCER ; GROWTH ; M2 ; METABOLISM ; DYSREGULATION ; INHIBITION ; DIAGNOSIS ; PROMOTES ; PKM2
WOS研究方向	Oncology
语种	英语
出版者	IVYSPRING INT PUBL
WOS记录号	WOS:000549095900002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292056]
专题	中国科学院上海药物研究所
通讯作者	You, Shanxi; Shi, Jumei; Zhu, Weiliang
作者单位	1.Taizhou Fourth Peoples Hosp, Dept Oncol, Taizhou 225300, Jiangsu, Peoples R China 2.Tongji Univ, Shanghai Peoples Hosp 10, Dept Hematol, Sch Med, Shanghai 200072, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Feng, Qilin,Yao, Qingchun,Li, Bo,et al. Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma[J]. JOURNAL OF CANCER,2020,11(16):4907-4916.
APA	Feng, Qilin.,Yao, Qingchun.,Li, Bo.,Xie, Yongsheng.,Zhang, Hui.,...&Zhu, Weiliang.(2020).Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma.JOURNAL OF CANCER,11(16),4907-4916.
MLA	Feng, Qilin,et al."Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma".JOURNAL OF CANCER 11.16(2020):4907-4916.