Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice

doi:10.1016/j.carbpol.2020.116357

	Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice
	Zhang, Xue 2,3; Hu, Pei 1; Zhang, Xiaorui 4; Li, Xiaojun 2,3
刊名	CARBOHYDRATE POLYMERS
	2020-07-15
卷号	240 页码:8
关键词	Lobelia chinensis Lour polysaccharides anti-obesity chemical structure inulin-type fructan high fat diet-induced mice
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2020.116357
通讯作者	Hu, Pei(hupeishtcm@126.com) ; Li, Xiaojun(juniors_li@163.com)
英文摘要	A neutral polysaccharide (LCPS) was obtained from Lobelia chinensis via hot water extraction and ethanol precipitation. After separation and purification, the homogeneous polysaccharide was obtained with a molecular weight of 2.6x10(3) Da. The chemical composition of the extracted polysaccharide contains fructose and glucose with protein-free identified by gas chromatography-mass spectrometer (GC-MS) method. Chemical structure of LCPS was indicated by nuclear magnetic resonance (NMR) spectroscopy. Data indicated that LCPS was an inulintype fructan with alpha-D-Glcp-(1 ->[1)-beta-D-Fruf-(2](15) linkage. LCPS intake reduced at significant level high fat diet (HFD)-induced body weight gain, liver weight, total cholesterol and triglyceride in serum and hepatic tissue, respectively. The lipid droplet accumulation in hepatic tissue was similar between lean and LCPS groups lower than in HFD-induced mice from tissue section staining results. Together, polysaccharides from Lobelia chinensis could be a new source of natural anti-obesity agent against obesity with potential value in the manufacturing supplements and drugs.
WOS关键词	GUT MICROBIOTA ; INDUCED OBESITY ; CALORIE RESTRICTION ; POLYSACCHARIDES ; OLIGOSACCHARIDES ; POLYMERIZATION ; CONSTITUENTS ; INFLAMMATION ; PERFORMANCE ; OVERWEIGHT
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000537314900013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291647]
专题	中国科学院上海药物研究所
通讯作者	Hu, Pei; Li, Xiaojun
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Medica, Shanghai, Peoples R China 2.Yangzhou Univ, Inst Translat Med, Med Coll, Yangzhou 225001, Jiangsu, Peoples R China 3.Yangzhou Univ, Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou 225001, Jiangsu, Peoples R China 4.CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xue,Hu, Pei,Zhang, Xiaorui,et al. Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice[J]. CARBOHYDRATE POLYMERS,2020,240:8.
APA	Zhang, Xue,Hu, Pei,Zhang, Xiaorui,&Li, Xiaojun.(2020).Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice.CARBOHYDRATE POLYMERS,240,8.
MLA	Zhang, Xue,et al."Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice".CARBOHYDRATE POLYMERS 240(2020):8.