Absolute configurations of new cembrane-type diterpenoids from the Hainan soft coral Sarcophyton crassocaule | |
Ye, Fei2,3; Gu, Yu-Cheng1; Guo, Yue-Wei2,3,4; Li, Xu-Wen2,3,4 | |
刊名 | TETRAHEDRON LETTERS |
2020-06-18 | |
卷号 | 61期号:25页码:4 |
关键词 | Soft coral Sarcophyton Cembranoids Absolute configuration |
ISSN号 | 0040-4039 |
DOI | 10.1016/j.tetlet.2020.152008 |
通讯作者 | Guo, Yue-Wei(ywguo@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn) |
英文摘要 | The determination of the stereochemistry of cembrane type diterpenoids is always a challenging task due to the flexibility of the 14-membered macrocycle. In this paper, three new cembranoids, ximaocembrols A-C (1-3), were isolated from the Hainan soft coral Sarcophyton crassocaule, and ximaocembrol C was further separated by chiral HPLC to its corresponding enantiomers (+/-)-3, respectively. The absolute configurations of these new compounds were successfully elucidated by using a series of reliable approaches, including extensive spectroscopic analysis, TDDFT-ECD calculation, modified Mosher's method, and Snatzke's method. (C) 2020 Elsevier Ltd. All rights reserved. |
资助项目 | National Key Research and Development Program of China[2018YFC0310903] ; Natural Science Foundation of China[81991521] ; NSFC/CNRS joint project[81811530284] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Chinese Academy of Sciences[2016258] ; SA-SIBS Scholarship Program ; Syngenta-SIMM-PhD Studentship Project |
WOS关键词 | MO-2(OAC)(4) |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000537694300009 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/291613] |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Guo, Yue-Wei; Li, Xu-Wen |
作者单位 | 1.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhaniang Hitech Pk, Shanghai 201203, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China |
推荐引用方式 GB/T 7714 | Ye, Fei,Gu, Yu-Cheng,Guo, Yue-Wei,et al. Absolute configurations of new cembrane-type diterpenoids from the Hainan soft coral Sarcophyton crassocaule[J]. TETRAHEDRON LETTERS,2020,61(25):4. |
APA | Ye, Fei,Gu, Yu-Cheng,Guo, Yue-Wei,&Li, Xu-Wen.(2020).Absolute configurations of new cembrane-type diterpenoids from the Hainan soft coral Sarcophyton crassocaule.TETRAHEDRON LETTERS,61(25),4. |
MLA | Ye, Fei,et al."Absolute configurations of new cembrane-type diterpenoids from the Hainan soft coral Sarcophyton crassocaule".TETRAHEDRON LETTERS 61.25(2020):4. |
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