Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities

doi:10.1002/cbdv.202000503

	Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities
	Hu, Yu-Hong 1,2; Liu, Jin 1; Li, Heng 1; Tang, Wei 1; Li, Xu-Wen 1; Guo, Yue-Wei 1
刊名	CHEMISTRY & BIODIVERSITY
	2020-10-16
页码	10
关键词	Citrus changshan-huyou limonoids structure modification anti-inflammation
ISSN号	1612-1872
DOI	10.1002/cbdv.202000503
通讯作者	Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	A systematically chemical investigation ofCitrus changshan-huyouY.B.Chang resulted in the isolation and structure determination of twelve known natural products, including limonoid, nootkatone, scoparone, beta-sitosterol, 3,3 ',4 ',5,6,7,8,-heptamethoxyflavone, nobiletin, tangeretin, naringin, hesperidin, neohesperidin, 3,5-dihydroxyphenyl beta-D-glucoside, beta-sitosterol-D-glucoside. The structure modification of the most abundant compound limonin further led to eight limonoid derivatives, including epi-limonol, epi-limonyl acetate, and six new compoundsepi-limonol A, limonol A, limonol B, epi-limonol B, epi-limonol C, epi-limonol D, which enlarged the chemical diversity of limonin related limonoids. The structures of the new limonoid derivatives were identified by extensive spectroscopic analysis. In bioassay, all the isolates, the semi-synthetic derivatives and the previously isolated limonoids in our natural product library were subjected for anti-inflammatory activities evaluation, and several limonoids exhibited the inhibition of TNF-alpha release.
资助项目	Drug Innovation Major Project[2018ZX09711-001-001-009]
WOS关键词	DERIVATIVES ; AGENTS ; IDENTIFICATION ; LIMONOIDS ; PEELS ; NMR
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000577602800001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291347]
专题	中国科学院上海药物研究所
通讯作者	Li, Xu-Wen; Guo, Yue-Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Zhanhong Biotechnol Co Ltd, Changshan Eco Ind Pk, Quzhou 324202, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Hu, Yu-Hong,Liu, Jin,Li, Heng,et al. Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities[J]. CHEMISTRY & BIODIVERSITY,2020:10.
APA	Hu, Yu-Hong,Liu, Jin,Li, Heng,Tang, Wei,Li, Xu-Wen,&Guo, Yue-Wei.(2020).Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities.CHEMISTRY & BIODIVERSITY,10.
MLA	Hu, Yu-Hong,et al."Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities".CHEMISTRY & BIODIVERSITY (2020):10.