Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging

doi:10.1002/chem.202002772

	Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging
	Dong, Lei 1,2,3; Fu, Mengqi 1,2; Liu, Lifang 1,2; Han, Hai-Hao 1,2; Zang, Yi 4; Chen, Guo-Rong 1,2; Li, Jia 4; He, Xiao-Peng 1,2; Vidal, Sebastien 3
刊名	CHEMISTRY-A EUROPEAN JOURNAL
	2020-10-06
页码	9
关键词	cell imaging glycoclusters peroxynitrite detection self-assembly tetraphenylethylene
ISSN号	0947-6539
DOI	10.1002/chem.202002772
通讯作者	Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; Vidal, Sebastien(sebastien.vidal@univ-lyon1.fr)
英文摘要	Two red-emitting dicyanomethylene-4H-pyran (DM) based fluorescent probes were designed and used for peroxynitrite (ONOO-) detection. Nevertheless, the aggregation-caused quenching effect diminished the fluorescence and restricted their further applications. To overcome this problem, tetraphenylethylene (TPE) based glycoclusters were used to self-assemble with these DM probes to obtain supramolecular water-soluble glyco-dots. This self-assembly strategy enhanced the fluorescence intensity, leading to an enhanced selectivity and activity of the resulting glyco-dot comparing to DM probes alone in PBS buffer. The glyco-dots also exhibited better results during fluorescence sensing of intracellular ONOO(-)than the probes alone, thereby offering scope for the development of other similar supramolecular glyco-systems for chemical biological studies.
资助项目	Universite Claude Bernard Lyon 1 ; CNRS ; Natural Science Foundation of China[21788102] ; Natural Science Foundation of China[91853201] ; Natural Science Foundation of China[21722801] ; Natural Science Foundation of China[21776078] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; National Key Sci-Tech Special Projects of Infection Diseases of China[2018ZX10732202] ; international cooperation program of Shanghai Science and Technology Committee[17520750100] ; China Scholarship Council[201606740066]
WOS关键词	PERYLENEDIIMIDE-BASED GLYCOCLUSTERS ; SELECTIVE DETECTION ; GALACTOSIDASE ; TRACKING ; RECEPTOR
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000575265700001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291309]
专题	中国科学院上海药物研究所
通讯作者	Li, Jia; He, Xiao-Peng; Vidal, Sebastien
作者单位	1.East China Univ Sci & Technol, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Frontiers Ctr Mat & Dynam Che, 130 Meilong Rd, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Frontiers Ctr Mat & Dynam Che, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.Univ Lyon, Inst Chim & Biochim Mol & Supramol, Lab Chim Organ 2 Glycochim, UMR 5246,CNRS,Univ Claude Bernard Lyon 1, 1 Rue Victor Grignard, F-69622 Villeurbanne, France 4.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Dong, Lei,Fu, Mengqi,Liu, Lifang,et al. Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging[J]. CHEMISTRY-A EUROPEAN JOURNAL,2020:9.
APA	Dong, Lei.,Fu, Mengqi.,Liu, Lifang.,Han, Hai-Hao.,Zang, Yi.,...&Vidal, Sebastien.(2020).Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging.CHEMISTRY-A EUROPEAN JOURNAL,9.
MLA	Dong, Lei,et al."Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging".CHEMISTRY-A EUROPEAN JOURNAL (2020):9.