RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE

doi:10.3987/COM-20-14258

	RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE
	Li, Siqi 1,2; Yu, Yang 2; Yang, Yaxi 1,3; Zhou, Bing 1,3
刊名	HETEROCYCLES
	2020-06-01
卷号	100 期号:6 页码:934-945
关键词	C-H Hydroxymethylation N-Aryl-azaindole
ISSN号	0385-5414
DOI	10.3987/COM-20-14258
通讯作者	Yu, Yang(yangyu2017@shu.edu.cn) ; Zhou, Bing(zhoubing@simm.ac.cn)
英文摘要	A facile synthesis of hydroxymethylated N-aryl-azaindoles was developed via a Ru(II)-catalyzed regioselective C-H addition to paraformaldehyde. The reaction is compatible with air, shows high functional group tolerance and regioselectivity, and is an environmentally benign method without any undesired byproduct.
资助项目	National Natural Science Foundation of China[21702218] ; National Natural Science Foundation of China[91753207] ; National major science and technology project major new drug creation[2018ZX09711002-006-001] ; National major science and technology project major new drug creation[2018ZX09711002-007] ; Youth Innovation Promotion Association[2017333] ; Shanghai Rising-Star Program[17QA1405000]
WOS关键词	RUTHENIUM-CATALYZED DIRECT ; 7-AZAINDOLES ; FUNCTIONALIZATION ; ALDEHYDES ; ACTIVATION ; ARYLATION ; ALKYLATION ; REACTIVITY ; INDOLINES ; INSERTION
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000571526900006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291216]
专题	中国科学院上海药物研究所
通讯作者	Yu, Yang; Zhou, Bing
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ, Coll Sci, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Siqi,Yu, Yang,Yang, Yaxi,et al. RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE[J]. HETEROCYCLES,2020,100(6):934-945.
APA	Li, Siqi,Yu, Yang,Yang, Yaxi,&Zhou, Bing.(2020).RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE.HETEROCYCLES,100(6),934-945.
MLA	Li, Siqi,et al."RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE".HETEROCYCLES 100.6(2020):934-945.