A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei

doi:10.1021/acs.jnatprod.8b00482

	A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei
	Feng, Lu 1; Mandi, Attila 2; Tang, Chunping 1,4; Kurtan, Tibor 2; Tang, Shuai 3; Ke, Chang-Qiang 1,4; Shen, Ning 3; Lin, Ge 4; Yao, Sheng 1,4; Ye, Yang 1,4,5
刊名	JOURNAL OF NATURAL PRODUCTS
	2018-12-01
卷号	81 期号:12 页码:2667-2672
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.8b00482
通讯作者	Yao, Sheng(yaosheng@simm.ac.cn) ; Ye, Yang()
英文摘要	(+/-)-Cryptomeriolide, a pair of racemic bis-seco-abietane diterpenoids, were isolated from the bark of Cryptomeria fortunei. The separation of enantiomers was achieved by using chiral stationary phase HPLC. Their structures including the absolute configuration and conformations in solution and solid state were determined by extensive analysis of spectroscopic data, single-crystal X-ray diffraction, and comparison of calculated and experimental electronic circular dichroism data. A bioinspired one-pot enantiomeric synthesis of 1a and 1b was accomplished via a readily made intermediate orthoquinone from sugiol. All compounds including the synthetic intermediates were assayed for their cytotoxic activities on human cancer cell lines HL-60, A549, and SGC7901.
资助项目	National Science & Technology Major Project of China Key New Drug Creation and Manufacturing Program[2015ZX09103002] ; National Natural Science Foundation of China[81473112] ; National Natural Science Foundation of China[81573305] ; International Partnership Program of the Chinese Academy of Sciences[153631KYSB20160004] ; National Research, Development and Innovation Office[NKFI K120181] ; National Research, Development and Innovation Office[PD121020]
WOS关键词	ABSOLUTE-CONFIGURATION ; LEAVES ; BARK
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000454962500008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290860]
专题	中国科学院上海药物研究所
通讯作者	Yao, Sheng; Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Nat Prod, Chem Dept, Shanghai 201203, Peoples R China 2.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary 3.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China 4.SIMM CUHK Joint Res Lab Promoting Globalizat Trad, Shanghai 201203, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Feng, Lu,Mandi, Attila,Tang, Chunping,et al. A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(12):2667-2672.
APA	Feng, Lu.,Mandi, Attila.,Tang, Chunping.,Kurtan, Tibor.,Tang, Shuai.,...&Ye, Yang.(2018).A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei.JOURNAL OF NATURAL PRODUCTS,81(12),2667-2672.
MLA	Feng, Lu,et al."A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei".JOURNAL OF NATURAL PRODUCTS 81.12(2018):2667-2672.