Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes

doi:10.1002/ejoc.201801602

	Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes
	Peng, Yingyuan 1; Zhang, Xiaofei 2; Qi, Xueyu 2; He, Qian 2; Zhang, Bin 1; Hao, Jian 1; Yang, Chunhao 2
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2019-02-07
期号	5 页码:1170-1177
关键词	Addition gem-Difluorostyrene Phosphorus alpha-Fluorovinyl Phosphine oxide
ISSN号	1434-193X
DOI	10.1002/ejoc.201801602
通讯作者	Hao, Jian(jhao@shu.edu.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要	A facile and efficient method for the synthesis of (E/Z)-alpha-fluorovinyl phosphorus compounds from gem-difluorostyrenes with diphenylphosphine oxide/dialkyl phosphate and DBU at room temperature was developed. A series of 1-fluorovinyl phosphine oxides/phosphonates were obtained with moderate to excellent yields in these reactions. Additionally, most isomers (E/Z type) of the target compounds could be easily separated and purified by column chromatography.
资助项目	National Natural Science Foundation of China[2150208] ; National Natural Science Foundation of China[21672139] ; SKLDR/SIMM[SIMM1601ZZ-03]
WOS关键词	ALPHA-FLUORINATED PHOSPHONATES ; CRAFTS-TYPE CYCLIZATION ; CATALYZED HYDROPHOSPHORYLATION ; DIFLUOROALKENES ; ALKYNES ; FLUOROALKENYLATION ; ACTIVATION ; ALKYLATION ; EFFICIENT ; GENERATE
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000458273900033
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290597]
专题	中国科学院上海药物研究所
通讯作者	Hao, Jian; Yang, Chunhao
作者单位	1.Shanghai Univ, Dept Chem, Innovat Drug Res Ctr, Shangda Rd 99, Shanghai 200436, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Peng, Yingyuan,Zhang, Xiaofei,Qi, Xueyu,et al. Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2019(5):1170-1177.
APA	Peng, Yingyuan.,Zhang, Xiaofei.,Qi, Xueyu.,He, Qian.,Zhang, Bin.,...&Yang, Chunhao.(2019).Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(5),1170-1177.
MLA	Peng, Yingyuan,et al."Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .5(2019):1170-1177.