Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature

doi:10.1093/gerona/gly048

	Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature
	Bacalini, Maria Giulia 2; Franceschi, Claudio 2,3,4; Gentilini, Davide 5; Ravaioli, Francesco 3; Zhou, Xiaoyuan 6,7,8; Remondini, Daniel 9,10; Pirazzini, Chiara 2; Giuliani, Cristina 11,12; Marasco, Elena 4; Gensous, Noemie 3
刊名	JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
	2019
卷号	74 期号:1 页码:1-8
关键词	DNA methylation Epigenetic clock Epithelialmesenchymal transition
ISSN号	1079-5006
DOI	10.1093/gerona/gly048
通讯作者	Franceschi, Claudio(claudio.franceschi@unibo.it)
英文摘要	The feasibility of liver transplantation from old healthy donors suggests that this organ is able to preserve its functionality during aging. To explore the biological basis of this phenomenon, we characterized the epigenetic profile of liver biopsies collected from 45 healthy liver donors ranging from 13 to 90 years old using the Infinium HumanMethylation450 BeadChip. The analysis indicates that a large remodeling in DNA methylation patterns occurs, with 8,823 age-associated differentially methylated CpG probes. Notably, these age-associated changes tended to level off after the age of 60, as confirmed by Horvaths clock. Using stringent selection criteria, we further identified a DNA methylation signature of aging liver including 75 genomic regions. We demonstrated that this signature is specific for liver compared to other tissues and that it is able to detect biological age-acceleration effects associated with obesity. Finally, we combined DNA methylation measurements with available expression data. Although the intersection between the two omic characterizations was low, both approaches suggested a previously unappreciated role of epithelialmesenchymal transition and Wnt-signaling pathways in the aging of human liver.
资助项目	Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) ; Horizon 2020 Framework Programme[634821] ; JPco-fuND ; H2020 Marie Sklodowska-Curie Actions[675003] ; [602757]
WOS关键词	EPITHELIAL-MESENCHYMAL TRANSITION ; DNA METHYLATION ; GENE-EXPRESSION ; HEPATOCELLULAR-CARCINOMA ; CELL-PROLIFERATION ; TUMOR-SUPPRESSOR ; AGE ; HYPERMETHYLATION ; CANCER ; FETAL
WOS研究方向	Geriatrics & Gerontology
语种	英语
出版者	OXFORD UNIV PRESS INC
WOS记录号	WOS:000462190200001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290210]
专题	中国科学院上海药物研究所
通讯作者	Franceschi, Claudio
作者单位	1.Ist Auxol Italiano IRCCS, Milan, Italy 2.IRCCS Ist Sci Neurol Bologna, Bologna, Italy 3.Alma Mater Studiorum, DIMES Dept Expt Diagnost & Specialty Med, Via San Giacomo 12, I-40126 Bologna, Italy 4.Alma Mater Studiorum, CIG, Interdept Ctr L Galvani, Bologna, Italy 5.Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy 6.Shanghai Inst Biol Sci, Grp Clin Genom Networks, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China 7.Univ Chinese Acad Sci, Beijing, Peoples R China 8.Univ San Francisco, Dept Neurol, San Francisco, CA 94117 USA 9.Alma Mater Studiorum, Dept Phys & Astron DIFA, Bologna, Italy 10.Alma Mater Studiorum, INFN Sez Bologna, Bologna, Italy
推荐引用方式 GB/T 7714	Bacalini, Maria Giulia,Franceschi, Claudio,Gentilini, Davide,et al. Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2019,74(1):1-8.
APA	Bacalini, Maria Giulia.,Franceschi, Claudio.,Gentilini, Davide.,Ravaioli, Francesco.,Zhou, Xiaoyuan.,...&Garagnani, Paolo.(2019).Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,74(1),1-8.
MLA	Bacalini, Maria Giulia,et al."Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 74.1(2019):1-8.