Optimization of taste-masking on ibuprofen microspheres with selected structure features

doi:10.1016/j.ajps.2018.05.003

	Optimization of taste-masking on ibuprofen microspheres with selected structure features
	Qin, Wei 1,2; He, Yuanzhi 1,2; Guo, Zhen 2; Zhang, Liu 2,3; Wu, Li 2; Yin, Xianzhen 2; Shakya, Shailendra 2,4; Maharjan, Abi 2,4; Tang, Yan 1,2; Zhu, Weifeng 1
刊名	ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2019-03-01
卷号	14 期号:2 页码:174-182
关键词	Ibuprofen microsphere Spray congealing Internal structure Synchrotron radiation X-ray micro-computed tomography
ISSN号	1818-0876
DOI	10.1016/j.ajps.2018.05.003
通讯作者	Zhu, Weifeng(zwf0322@126.com.net) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要	The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable taste of ibuprofen via three kinds of spray congealing processes, namely, air-cooling, water-cooling and citric acid solution-cooling. The stereoscopic and internal structures of ibuprofen microspheres were quantitatively analyzed by synchrotron radiation X-ray micro-computed tomography (SR-mu CT) to establish the relationship between the preparation process and microsphere architectures. It was found that the microstructure and morphology of the microspheres were significantly influenced by preparation processes as the primary factors to determine the release profiles and taste-masking effects. The sphericity of ibuprofen microspheres congealed in citric acid solution was higher than that of other two and its morphology was more regular than that being congealed in air or distilled water, and the contact angles between congealing media and melted ibuprofen in octadecanol and glycerin monostearate well demonstrated the structure differences among microspheres of three processes which controlled the release characteristics of the microspheres. The structure parameters like porosity, sphericity, and radius ratio from quantitative analysis were correlated well with drug release behaviors. The results demonstrated that the exterior morphology and internal structure of microspheres had considerable influences on the drug release behaviors as well as taste-masking effects. (C) 2018 Shenyang Pharmaceutical University. Published by Elsevier B.V.
资助项目	National Natural Science Foundation of China[81773645] ; National Science and Technology Major Projects for the Major New Drugs Innovation and Development[2017ZX09101001-006]
WOS关键词	X-RAY MICROTOMOGRAPHY ; ORODISPERSIBLE TABLETS ; CONTROLLED-RELEASE ; IN-VITRO ; SUSPENSION ; GRANULES
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	SHENYANG PHARMACEUTICAL UNIV
WOS记录号	WOS:000462072200006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290148]
专题	中国科学院上海药物研究所
通讯作者	Zhu, Weifeng; Zhang, Jiwen
作者单位	1.Jiangxi Univ Tradit Chinese Med, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China 4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Qin, Wei,He, Yuanzhi,Guo, Zhen,et al. Optimization of taste-masking on ibuprofen microspheres with selected structure features[J]. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2019,14(2):174-182.
APA	Qin, Wei.,He, Yuanzhi.,Guo, Zhen.,Zhang, Liu.,Wu, Li.,...&Zhang, Jiwen.(2019).Optimization of taste-masking on ibuprofen microspheres with selected structure features.ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,14(2),174-182.
MLA	Qin, Wei,et al."Optimization of taste-masking on ibuprofen microspheres with selected structure features".ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 14.2(2019):174-182.