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Optimization of taste-masking on ibuprofen microspheres with selected structure features
Qin, Wei1,2; He, Yuanzhi1,2; Guo, Zhen2; Zhang, Liu2,3; Wu, Li2; Yin, Xianzhen2; Shakya, Shailendra2,4; Maharjan, Abi2,4; Tang, Yan1,2; Zhu, Weifeng1
刊名ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
2019-03-01
卷号14期号:2页码:174-182
关键词Ibuprofen microsphere Spray congealing Internal structure Synchrotron radiation X-ray micro-computed tomography
ISSN号1818-0876
DOI10.1016/j.ajps.2018.05.003
通讯作者Zhu, Weifeng(zwf0322@126.com.net) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable taste of ibuprofen via three kinds of spray congealing processes, namely, air-cooling, water-cooling and citric acid solution-cooling. The stereoscopic and internal structures of ibuprofen microspheres were quantitatively analyzed by synchrotron radiation X-ray micro-computed tomography (SR-mu CT) to establish the relationship between the preparation process and microsphere architectures. It was found that the microstructure and morphology of the microspheres were significantly influenced by preparation processes as the primary factors to determine the release profiles and taste-masking effects. The sphericity of ibuprofen microspheres congealed in citric acid solution was higher than that of other two and its morphology was more regular than that being congealed in air or distilled water, and the contact angles between congealing media and melted ibuprofen in octadecanol and glycerin monostearate well demonstrated the structure differences among microspheres of three processes which controlled the release characteristics of the microspheres. The structure parameters like porosity, sphericity, and radius ratio from quantitative analysis were correlated well with drug release behaviors. The results demonstrated that the exterior morphology and internal structure of microspheres had considerable influences on the drug release behaviors as well as taste-masking effects. (C) 2018 Shenyang Pharmaceutical University. Published by Elsevier B.V.
资助项目National Natural Science Foundation of China[81773645] ; National Science and Technology Major Projects for the Major New Drugs Innovation and Development[2017ZX09101001-006]
WOS关键词X-RAY MICROTOMOGRAPHY ; ORODISPERSIBLE TABLETS ; CONTROLLED-RELEASE ; IN-VITRO ; SUSPENSION ; GRANULES
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者SHENYANG PHARMACEUTICAL UNIV
WOS记录号WOS:000462072200006
内容类型期刊论文
源URL[http://119.78.100.183/handle/2S10ELR8/290148]  
专题中国科学院上海药物研究所
通讯作者Zhu, Weifeng; Zhang, Jiwen
作者单位1.Jiangxi Univ Tradit Chinese Med, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China
4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Qin, Wei,He, Yuanzhi,Guo, Zhen,et al. Optimization of taste-masking on ibuprofen microspheres with selected structure features[J]. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2019,14(2):174-182.
APA Qin, Wei.,He, Yuanzhi.,Guo, Zhen.,Zhang, Liu.,Wu, Li.,...&Zhang, Jiwen.(2019).Optimization of taste-masking on ibuprofen microspheres with selected structure features.ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,14(2),174-182.
MLA Qin, Wei,et al."Optimization of taste-masking on ibuprofen microspheres with selected structure features".ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 14.2(2019):174-182.
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