One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water

doi:10.3390/molecules24050893

	One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water
	Chen, Liang 1,2,3; Zhu, Huajian 1,2,3; Wang, Jiang 2,3; Liu, Hong 1,2,3
刊名	MOLECULES
	2019-03-01
卷号	24 期号:5 页码:13
关键词	NBS nitrogen-containing heterocycle water one-pot
ISSN号	1420-3049
DOI	10.3390/molecules24050893
通讯作者	Wang, Jiang(jwang@simm.ac.cn) ; Liu, Hong(hliu@simm.ac.cn)
英文摘要	A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of alpha-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions.
资助项目	National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21672231] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304]
WOS关键词	N-BROMOSUCCINIMIDE ; ORGANIC-SYNTHESIS ; IMIDAZOPYRIDINES ; ZOLIMIDINE ; CHEMISTRY ; OXIDATION ; SULFONES ; GREEN ; ARYL ; BOND
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000462662900069
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290137]
专题	中国科学院上海药物研究所
通讯作者	Wang, Jiang; Liu, Hong
作者单位	1.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen, Liang,Zhu, Huajian,Wang, Jiang,et al. One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water[J]. MOLECULES,2019,24(5):13.
APA	Chen, Liang,Zhu, Huajian,Wang, Jiang,&Liu, Hong.(2019).One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water.MOLECULES,24(5),13.
MLA	Chen, Liang,et al."One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water".MOLECULES 24.5(2019):13.