Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C-H bonds utilizing amino acids as a directing group

doi:10.1039/c9ra00749k

	Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C-H bonds utilizing amino acids as a directing group
	Cong, Zhanqing 1,2,3; Gao, Feng 2,3; Liu, Hong 1,2,3
刊名	RSC ADVANCES
	2019
卷号	9 期号:19 页码:10820-10824
ISSN号	2046-2069
DOI	10.1039/c9ra00749k
通讯作者	Liu, Hong(hliu@simm.ac.cn)
英文摘要	The nickel(ii)-catalyzed ortho-arylation of unactivated C-H bonds utilizing amino acids as directing groups with aryl iodides or bromides as coupling electrophiles is described. This protocol features excellent mono-selectivity, good regioselectivity, and wide functional group tolerance. Additionally, the obtained products bearing a biaryl motif and an amino acid represent bioactive molecules with wide bioactivities.
资助项目	National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81602975] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304]
WOS关键词	BETA-C(SP(3))-H ARYLATION ; INTRAMOLECULAR AMINATION ; C(SP(2))-H BONDS ; C(SP(3))-H BONDS ; FUNCTIONALIZATION ; DERIVATIVES ; ACTIVATION ; BENZAMIDES ; 8-AMINOQUINOLINE ; THIOLATION
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000465297300044
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289940]
专题	中国科学院上海药物研究所
通讯作者	Liu, Hong
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Cong, Zhanqing,Gao, Feng,Liu, Hong. Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C-H bonds utilizing amino acids as a directing group[J]. RSC ADVANCES,2019,9(19):10820-10824.
APA	Cong, Zhanqing,Gao, Feng,&Liu, Hong.(2019).Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C-H bonds utilizing amino acids as a directing group.RSC ADVANCES,9(19),10820-10824.
MLA	Cong, Zhanqing,et al."Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C-H bonds utilizing amino acids as a directing group".RSC ADVANCES 9.19(2019):10820-10824.