Synchrotron radiation micro-tomography for high-resolution neurovascular network morphology investigation

doi:10.1107/S1600577519003060

	Synchrotron radiation micro-tomography for high-resolution neurovascular network morphology investigation
	Cao, Yong 4,5,6; Zhang, Mengqi 7; Ding, Hui 7; Chen, Zhuohui 7; Tang, Bin 7; Wu, Tianding 4,5,6; Xiao, Bo 7; Duan, Chunyue 4,5,6; Ni, Shuangfei 4,5,6; Jiang, Liyuan 4,5,6
刊名	JOURNAL OF SYNCHROTRON RADIATION
	2019-05-01
卷号	26 页码:607-618
关键词	high-resolution imaging neurovascular network 3D
ISSN号	0909-0495
DOI	10.1107/S1600577519003060
通讯作者	Lu, Hongbin(hongbinlu@hotmail.com) ; Hu, Jianzhong(jianzhonghu@hotmail.com)
英文摘要	There has been increasing interest in using high-resolution micro-tomography to investigate the morphology of neurovascular networks in the central nervous system, which remain difficult to characterize due to their microscopic size as well as their delicate and complex 3D structure. Synchrotron radiation X-ray imaging, which has emerged as a cutting-edge imaging technology with a high spatial resolution, provides a novel platform for the non-destructive imaging of microvasculature networks at a sub-micrometre scale. When coupled with computed tomography, this technique allows the characterization of the 3D morphology of vasculature. The current review focuses on recent progress in developing synchrotron radiation methodology and its application in probing neurovascular networks, especially the pathological changes associated with vascular abnormalities in various model systems. Furthermore, this tool represents a powerful imaging modality that improves our understanding of the complex biological interactions between vascular function and neuronal activity in both physiological and pathological states.
资助项目	National Natural Science Foundation of China[81501025] ; National Natural Science Foundation of China[81371956] ; National Natural Science Foundation of China[81171698] ; National Natural Science Foundation of China[81672174] ; National Natural Science Foundation of China[81730068] ; National Natural Science Foundation of China[81472072] ; National Natural Science Foundation of China[81171699] ; National Natural Science Foundation of China[61772556] ; Natural Science Foundation of Hunan Province[2016JJ3174] ; Natural Science Foundation of Hunan Province[2017JJ2330] ; Science Foundation of Xiangya Hospital for Young Scholar[2017Q1] ; Changsha Science and Technology Plan Key Project[kq1801066] ; Science and Technology Commission of Hunan Province of China[2017SK2061]
WOS关键词	CEREBRAL-ARTERY OCCLUSION ; RAY COMPUTED-TOMOGRAPHY ; PHASE-CONTRAST ; SPINAL-CORD ; 3-DIMENSIONAL ALTERATION ; MEDICAL APPLICATIONS ; IN-SITU ; VISUALIZATION ; ANGIOGRAPHY ; MODEL
WOS研究方向	Instruments & Instrumentation ; Optics ; Physics
语种	英语
出版者	INT UNION CRYSTALLOGRAPHY
WOS记录号	WOS:000467526100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289895]
专题	中国科学院上海药物研究所
通讯作者	Lu, Hongbin; Hu, Jianzhong
作者单位	1.Cent S Univ, Sch Informat Sci & Engn, Changsha 410008, Hunan, Peoples R China 2.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai Synchrotron Radiat Facil, Shanghai 21204, Peoples R China 3.Cent S Univ, Xiangya Hosp, Dept Sport Med, Changsha 410008, Hunan, Peoples R China 4.Cent S Univ, Xiangya Hosp, Dept Spine Surg, Changsha 410008, Hunan, Peoples R China 5.Key Lab Organ Injury Aging & Regenerat Med Hunan, Changsha 410008, Hunan, Peoples R China 6.Xiangya Hosp, Int Chinese Musculoskeletal Res Soc, Sports Med Res Ctr, Changsha 410008, Hunan, Peoples R China 7.Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 20203, Peoples R China
推荐引用方式 GB/T 7714	Cao, Yong,Zhang, Mengqi,Ding, Hui,et al. Synchrotron radiation micro-tomography for high-resolution neurovascular network morphology investigation[J]. JOURNAL OF SYNCHROTRON RADIATION,2019,26:607-618.
APA	Cao, Yong.,Zhang, Mengqi.,Ding, Hui.,Chen, Zhuohui.,Tang, Bin.,...&Hu, Jianzhong.(2019).Synchrotron radiation micro-tomography for high-resolution neurovascular network morphology investigation.JOURNAL OF SYNCHROTRON RADIATION,26,607-618.
MLA	Cao, Yong,et al."Synchrotron radiation micro-tomography for high-resolution neurovascular network morphology investigation".JOURNAL OF SYNCHROTRON RADIATION 26(2019):607-618.