Pd-Catalyzed Site-Selective C(sp(2))-H Olefination and Alkynylation of Phenylalanine Residues in Peptides

doi:10.1021/acs.orglett.9b00987

	Pd-Catalyzed Site-Selective C(sp(2))-H Olefination and Alkynylation of Phenylalanine Residues in Peptides
	Zheng, Yong 2; Song, Weibin 1
刊名	ORGANIC LETTERS
	2019-05-03
卷号	21 期号:9 页码:3257-3260
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b00987
通讯作者	Song, Weibin(songwbolin@163.com)
英文摘要	Pd-catalyzed site-selective C(sp(2))-H olefination and alkynylation of phenylalanine residues in peptides are described. The amino acids within the peptides are used as native bidentate directing groups to facilitate C-H functionalization. This protocol would provide appealing strategies for the postsynthetic modification of peptides.
资助项目	National Natural Science Foundation of China[81602995]
WOS关键词	C-H ALKYNYLATION ; PALLADIUM(II)-CATALYZED ORTHO-OLEFINATION ; ACTIVATION ; ALKENYLATION ; ARENES ; FUTURE ; BONDS ; DIVERSIFICATION ; AMIDES ; MILD
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000467320000060
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289710]
专题	中国科学院上海药物研究所
通讯作者	Song, Weibin
作者单位	1.Nanjing Univ Chinese Med, Sch Pharm, Jiangsu Key Lab Funct Subst Chinese Med, Stake Key Lab Cultivat Base TCM Qual & Efficacy, Nanjing 210023, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Yong,Song, Weibin. Pd-Catalyzed Site-Selective C(sp(2))-H Olefination and Alkynylation of Phenylalanine Residues in Peptides[J]. ORGANIC LETTERS,2019,21(9):3257-3260.
APA	Zheng, Yong,&Song, Weibin.(2019).Pd-Catalyzed Site-Selective C(sp(2))-H Olefination and Alkynylation of Phenylalanine Residues in Peptides.ORGANIC LETTERS,21(9),3257-3260.
MLA	Zheng, Yong,et al."Pd-Catalyzed Site-Selective C(sp(2))-H Olefination and Alkynylation of Phenylalanine Residues in Peptides".ORGANIC LETTERS 21.9(2019):3257-3260.