SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC

doi:10.1080/15548627.2019.1632122

	SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC
	Zhang, Sulin 1,2; Yang, Zhiwen 3; Bao, Weilian 1; Liu, Lixin 1; You, Yan 1; Wang, Xu 1; Shao, Liming 1; Fu, Wei 1; Kou, Xinhui 1; Shen, Weixing 4
刊名	AUTOPHAGY
	2019-07-05
页码	15
关键词	Colorectal cancer macroautophagy SNX10 SRC tumor growth
ISSN号	1554-8627
DOI	10.1080/15548627.2019.1632122
通讯作者	Zheng, Mingyue(myzheng@simm.ac.cn) ; Shen, Xiaoyan(shxiaoy@fudan.edu.cn)
英文摘要	The non-receptor tyrosine kinase SRC is a key mediator of cellular protumorigenic signals. SRC is aberrantly over-expressed and activated in more than 80% of colorectal cancer (CRC) patients, therefore regulation of its stability and activity is essential. Here, we report a significant down regulation of SNX10 (sorting nexin 10) in human CRC tissues, which is closely related to tumor differentiation, TNM stage, lymph node metastasis and survival period. SNX10 deficiency in normal and neoplastic colorectal epithelial cells promotes initiation and progression of CRC in mice. SNX10 controls SRC levels by mediating autophagosome-lysosome fusion and SRC recruitment for autophagic degradation. These mechanisms ensure proper controlling of the activities of SRC-STAT3 and SRC-CTNNB1 signaling pathways by up-regulating SNX10 expression under stress conditions. These findings suggest that SNX10 acts as a tumor suppressor in CRC and it could be a potential therapeutic target for future development.
资助项目	National Natural Science Foundation of China[81773744] ; National Natural Science Foundation of China[81573441] ; National Natural Science Foundation of China[81371923] ; China Postdoctoral Science Foundation[2018M642122] ; Shanghai Sailing Program[19YF1457800]
WOS关键词	CHAPERONE-MEDIATED AUTOPHAGY ; STAT3 ; EXPRESSION ; INFLAMMATION ; ACTIVATION ; REVEALS ; ROLES ; CELLS ; MODEL ; IL-6
WOS研究方向	Cell Biology
语种	英语
出版者	TAYLOR & FRANCIS INC
WOS记录号	WOS:000475048000001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289346]
专题	中国科学院上海药物研究所
通讯作者	Zheng, Mingyue; Shen, Xiaoyan
作者单位	1.Fudan Univ, Sch Pharm, Dept Pharmacol, 826 Zhangheng Rd, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Shanghai Jiao Tong Univ, Affiliated Shanghai Peoples Hosp 1, Songjiang Hosp, Dept Pharm, Shanghai, Peoples R China 4.Nanjing Univ Tradit Chinese Med, Translat Med Res Ctr, Nanjing, Jiangsu, Peoples R China 5.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Sulin,Yang, Zhiwen,Bao, Weilian,et al. SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC[J]. AUTOPHAGY,2019:15.
APA	Zhang, Sulin.,Yang, Zhiwen.,Bao, Weilian.,Liu, Lixin.,You, Yan.,...&Shen, Xiaoyan.(2019).SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC.AUTOPHAGY,15.
MLA	Zhang, Sulin,et al."SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC".AUTOPHAGY (2019):15.