Highly diverse cembranoids from the South China Sea soft coral Sinularia scabra as a new class of potential immunosuppressive agents

doi:10.1016/j.bmc.2019.06.030

	Highly diverse cembranoids from the South China Sea soft coral Sinularia scabra as a new class of potential immunosuppressive agents
	Yang, Min 1,2; Li, Heng 2,3; Zhang, Quan 1; Wu, Qi-Hao 1; Li, Geng 1,2; Chen, Kai-Xian 1,4; Guo, Yue-Wei 1,2,4; Tang, Wei 2,3,4; Li, Xu-Wen 1,2,4
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2019-08-01
卷号	27 期号:15 页码:3469-3476
关键词	Marine natural products Cembranoids Soft coral Sinularia scabra Immunosuppressive activity Structure-activity relationship
ISSN号	0968-0896
DOI	10.1016/j.bmc.2019.06.030
通讯作者	Guo, Yue-Wei(ywguo@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn)
英文摘要	The first and in-depth chemical investigation of the South China Sea soft coral Sinularia scabra has resulted to the isolation of a library of diverse cembrane type diterpenoids, including six new compounds, namely xiguscabrates A and B (1 and 2), xiguscabral A (3), xiguscabrols A and B (4 and 5), and 8-epi-xiguscabrol B (6), and twenty-seven known analogs (7-33). Their structures were elucidated by extensive spectroscopic analysis and by the comparison with literature data. In bioassay, several isolates exhibited inhibitory effects on the ConA-induced T lymphocytes and/or LPS-induced B lymphocytes proliferation. Among them, compound 24 showed considerable specific inhibition on B cell proliferation, with IC50 value of 4.4 mu M and selectivity index (SI) of 10.9. The structure-activity relationship (SAR) of the tested metabolites was analyzed, and the further mechanism study of the specific B-cell targeted immunosuppressive compound 24 on purified CD19(+) B cells was also performed to uncover the effects on the function and maturity of B cells, including cytokines production, abnormal activation, antigen presenting capacity and plasma cells formation.
资助项目	National Key Research and Development Program of China[2018YFC0310903] ; National Natural Science Foundation of China (NSFC)[81603022] ; National Natural Science Foundation of China (NSFC)[81520108028] ; National Natural Science Foundation of China (NSFC)[21672230] ; National Natural Science Foundation of China (NSFC)[81811530284] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Youth Innovation Promotion Association from Chinese Academy of Sciences[2016258] ; SA-SIBS Scholarship Program
WOS关键词	MARINE TERPENES ; PLASMA-CELLS ; B-CELLS ; DITERPENES ; NORDITERPENOIDS ; INVERTEBRATES
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000476649400028
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289054]
专题	中国科学院上海药物研究所
通讯作者	Guo, Yue-Wei; Tang, Wei; Li, Xu-Wen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, Shanghai 201203, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Yang, Min,Li, Heng,Zhang, Quan,et al. Highly diverse cembranoids from the South China Sea soft coral Sinularia scabra as a new class of potential immunosuppressive agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2019,27(15):3469-3476.
APA	Yang, Min.,Li, Heng.,Zhang, Quan.,Wu, Qi-Hao.,Li, Geng.,...&Li, Xu-Wen.(2019).Highly diverse cembranoids from the South China Sea soft coral Sinularia scabra as a new class of potential immunosuppressive agents.BIOORGANIC & MEDICINAL CHEMISTRY,27(15),3469-3476.
MLA	Yang, Min,et al."Highly diverse cembranoids from the South China Sea soft coral Sinularia scabra as a new class of potential immunosuppressive agents".BIOORGANIC & MEDICINAL CHEMISTRY 27.15(2019):3469-3476.