Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules

	Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules
	Miao, William G.2; Tang, Chunping 1; Ye, Yang 1; Quinn, Ronald J.2; Feng, Yunjiang 2
刊名	CHINESE JOURNAL OF NATURAL MEDICINES
	2019-09-01
卷号	17 期号:9 页码:713-720
关键词	Extraction Traditional Chinese medicine (TCM) Natural products Lipinski's Ro5Physicochemical properties
ISSN号	2095-6975
通讯作者	Quinn, Ronald J.(r.quinn@griffith.edu.au) ; Feng, Yunjiang(y.feng@griffith.edu.au)
英文摘要	Traditional Chinese Medicine (TCM) is an important reservoir for bioactive natural products. TCM extraction methods by water decoction and wine tincture are an integral part of TCM and essential for their widely acknowledged efficacy. In this study, we selected 6 common TCMs that are rich in chemistry to investigate whether the TCM extraction methods deliver molecules with drug-like physical chemical properties. Six TCM herbal materials were extracted by water, 95% ethanol, and sequential hexane, dichloromethane and methanol. The extracts were analyzed by HPLC and H-1 NMR. Isolation on one of the extracts yielded 32 compounds, their physical chemical properties were analyzed by Instant JChem. Our results showed that ethanol extraction, which mimics TCM wine tincture, delivered compounds with physical chemical properties compliant to Lipinski's rule of 5.
WOS关键词	PHENOLIC-COMPOUNDS ; HERBAL MEDICINES ; GASTRODIA-ELATA ; CONSTITUENTS ; DISCOVERY ; INHIBITION ; PRINCIPLES ; RHIZOMES
WOS研究方向	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种	英语
出版者	CHINESE JOURNAL NATURAL MEDICINES
WOS记录号	WOS:000485870100009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288805]
专题	中国科学院上海药物研究所
通讯作者	Quinn, Ronald J.; Feng, Yunjiang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Griffith Univ, Griffith Inst Drug Discovery GRIDD, Nathan, Qld 4111, Australia
推荐引用方式 GB/T 7714	Miao, William G.,Tang, Chunping,Ye, Yang,et al. Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(9):713-720.
APA	Miao, William G.,Tang, Chunping,Ye, Yang,Quinn, Ronald J.,&Feng, Yunjiang.(2019).Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules.CHINESE JOURNAL OF NATURAL MEDICINES,17(9),713-720.
MLA	Miao, William G.,et al."Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules".CHINESE JOURNAL OF NATURAL MEDICINES 17.9(2019):713-720.