Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens

doi:10.1021/acs.orglett.9b02630

	Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens
	Gao, Xin-Hua 2; Fan, Yao-Yue 2; Liu, Qun-Fang 2; Cho, Sang-Hyun 1; Pauli, Guido F.1; Chen, Shao-Nong 1; Yue, Jian-Min 2
刊名	ORGANIC LETTERS
	2019-09-06
卷号	21 期号:17 页码:7065-7068
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b02630
通讯作者	Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要	The suadimins A-C (1-3) from Melodinus suaveolens are the first example of monoterpenoid quinoline alkaloid dimers featuring an unprecedented carbon skeleton. Their structures and absolute configurations were established on the basis of extensive spectroscopic analyses, electric circular dichroism (ECD), and X-ray crystallography. Suadimin A showed significant antimycobacterial activity in vitro with an MIC90 of 6.76 mu M against the H(37)Rv strain of M. tuberculosis.
资助项目	National Natural Science Foundation of China[81861138045] ; National Natural Science Foundation of China[21532007] ; Drug Innovation Major Project of China[2018ZX09711001-001-005] ; Biological Resources Program, CAS of China[KFJ-BRP-008]
WOS关键词	CYTOTOXIC INDOLE ALKALOIDS ; BISINDOLE ALKALOIDS ; NATURAL-PRODUCTS ; CRYSTALLOGRAPHY
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000485089300096
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288768]
专题	中国科学院上海药物研究所
通讯作者	Yue, Jian-Min
作者单位	1.Univ Illinois, Coll Pharm, Inst TB Res, 833 South Wood St, Chicago, IL 60612 USA 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Gao, Xin-Hua,Fan, Yao-Yue,Liu, Qun-Fang,et al. Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens[J]. ORGANIC LETTERS,2019,21(17):7065-7068.
APA	Gao, Xin-Hua.,Fan, Yao-Yue.,Liu, Qun-Fang.,Cho, Sang-Hyun.,Pauli, Guido F..,...&Yue, Jian-Min.(2019).Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens.ORGANIC LETTERS,21(17),7065-7068.
MLA	Gao, Xin-Hua,et al."Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens".ORGANIC LETTERS 21.17(2019):7065-7068.