Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens

doi:10.1039/c9qo00820a

	Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens
	Zang, Yi 2; Gong, Yi-Hua 2; Li, Xu-Wen 3; Li, Xiao-Nian 1; Liu, Jun-Jun 2; Chen, Chun-Mei 2; Zhou, Yuan 2; Gu, Liang-Hu 2; Luo, Zeng-Wei 2; Wang, Jian-Ping 2
刊名	ORGANIC CHEMISTRY FRONTIERS
	2019-09-21
卷号	6 期号:18 页码:3274-3281
ISSN号	2052-4129
DOI	10.1039/c9qo00820a
通讯作者	Sun, Wei-Guang(weiguang_s@hust.edu.cn) ; Zhu, Hu-Cheng(zhuhucheng@hust.edu.cn) ; Zhang, Yong-Hui(zhangyh@mails.tjmu.edu.cn)
英文摘要	Three pairs of enantiomers (+/-)-canescones A-C (1-3), along with a pair of stereoisomers canescones D (4) and E (5), aromatic polyketide dimers bearing unprecedented 5/6/6/6/5 heterocyclic chemical architectures with a rare pentacyclic dihydrobenzo[1,4]dioxine core, were isolated from the fungus Penicillium canescens. Structure elucidation unambiguously suggests that 1 and 2 feature a new cyclopentanone ring A rather than a pyrrolidinone or furanone ring present in 3-5. All compounds were assayed for PTP1B inhibitory activity, and their hypothetical biosynthetic pathways were proposed.
资助项目	Program for Changjiang Scholars of Ministry of Education of the People's Republic of China[T2016088] ; National Natural Science Foundation for Distinguished Young Scholars of China[81725021] ; Innovative Research Groups of the National Natural Science Foundation of China[81721005] ; National Natural Science Foundation for Young Scientists of China[31800285] ; Academic Frontier Youth Team of HUST ; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST) ; Program from the China Postdoctoral Science Foundation[2017M622460]
WOS关键词	NATURAL-PRODUCTS ; BIOMIMETIC SYNTHESIS ; INSULIN SENSITIVITY ; PROTEIN
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000484960000014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288637]
专题	中国科学院上海药物研究所
通讯作者	Sun, Wei-Guang; Zhu, Hu-Cheng; Zhang, Yong-Hui
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zang, Yi,Gong, Yi-Hua,Li, Xu-Wen,et al. Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(18):3274-3281.
APA	Zang, Yi.,Gong, Yi-Hua.,Li, Xu-Wen.,Li, Xiao-Nian.,Liu, Jun-Jun.,...&Zhang, Yong-Hui.(2019).Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens.ORGANIC CHEMISTRY FRONTIERS,6(18),3274-3281.
MLA	Zang, Yi,et al."Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens".ORGANIC CHEMISTRY FRONTIERS 6.18(2019):3274-3281.