switchingoffimmp2lsignalingdrivessenescenceviasimultaneousmetabolicalterationandblockageofcelldeath

	switchingoffimmp2lsignalingdrivessenescenceviasimultaneousmetabolicalterationandblockageofcelldeath
	Yuan Lifeng 1; Zhai Linhui 2; Qian Lili 2; Huang De 1; Ding Yi 1; Xiang Handan 1; Liu Xiaojing 1; Thompson J Will 1; Liu Juan 1; He Yonghan 3
刊名	cellresearch
	2018
卷号	28 期号:6 页码:625
ISSN号	1001-0602
英文摘要	cellular senescence is a fundamental cell fate playing a significant role throughout the natural aging process. however, themolecular determinants distinguishing senescence from other cell-cycle arrest states such as quiescence and post-mitotic state, andthe specified mechanisms underlying cell-fate decisions towards senescence versus cell death in response to cellular stress stimuliremain less understood. employing multi-omics approaches, we revealed that switching off the specific mitochondrial processingmachinery involving the peptidase immp2l serves as the foundation of the senescence program, which was also observed duringthe mammalian aging process. mechanistically, we demonstrate that immp2l processes and thus activates at least two substrates,mitochondrial metabolic enzyme glycerol-3-phosphate dehydrogenase (gpd2) and cell death regulator apoptosis-inducing factor(aif). for cells destined to senesce, concerted shutdown of the immp2l-gpd2 and immp2l-aif signaling axes collaboratively drivesthe senescent process by reprogramming mitochondria-associated redox status, phospholipid metabolism and signaling network,and simultaneously blocking cell death under oxidative stress conditions.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/287900]
专题	中国科学院上海药物研究所
作者单位	1.杜克大学医学院 2.中国科学院上海药物研究所 3.中国科学院昆明动物研究所
推荐引用方式 GB/T 7714	Yuan Lifeng,Zhai Linhui,Qian Lili,et al. switchingoffimmp2lsignalingdrivessenescenceviasimultaneousmetabolicalterationandblockageofcelldeath[J]. cellresearch,2018,28(6):625.
APA	Yuan Lifeng.,Zhai Linhui.,Qian Lili.,Huang De.,Ding Yi.,...&Wang Xiaofan.(2018).switchingoffimmp2lsignalingdrivessenescenceviasimultaneousmetabolicalterationandblockageofcelldeath.cellresearch,28(6),625.
MLA	Yuan Lifeng,et al."switchingoffimmp2lsignalingdrivessenescenceviasimultaneousmetabolicalterationandblockageofcelldeath".cellresearch 28.6(2018):625.