designsynthesisandbiologicalevaluationofacylhydrazonederivativesaspi3kinhibitors

doi:10.1016/j.cclet.2014.10.016

	designsynthesisandbiologicalevaluationofacylhydrazonederivativesaspi3kinhibitors
	Gao Guorui 1; Liu Jiali 2; Mei Desheng 3; Ding Jian 2; Meng Linghua 2; Duan Wenhu 1
刊名	chinesechemicalletters
	2015
卷号	26 期号:1 页码:118
关键词	PI3-KINASE P110-ALPHA INHIBITORS 3-KINASE PATHWAY PI3K Inhibitor Aclhydrazone
ISSN号	1001-8417
DOI	10.1016/j.cclet.2014.10.016
英文摘要	Since the PI3K signaling pathway is the most commonly activated in human cancers, inhibition of PI3K K is a promising approach to cancer therapy. In this study, a series of 2-methyl-5-nitrobenzeneacylhydrazones were designed and synthesized. All the new derivatives were tested by p110 alpha enzymatic and Rh30 cellular assays. Further enzyme selectivity profiling proved that 6e and 7 were potential selective P13K inhibitors. (C) 2014 Ling-Hua Meng and Wen-Hu Duan. Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved.
资助项目	[National Natural Science Foundation of China] ; [Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"] ; [Chinese National Programs for High Technology Research and Development] ; [Shanghai Science and Technology Commission]
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/285038]
专题	中国科学院上海药物研究所
作者单位	1.华东理工大学 2.中国科学院 3.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Gao Guorui,Liu Jiali,Mei Desheng,et al. designsynthesisandbiologicalevaluationofacylhydrazonederivativesaspi3kinhibitors[J]. chinesechemicalletters,2015,26(1):118.
APA	Gao Guorui,Liu Jiali,Mei Desheng,Ding Jian,Meng Linghua,&Duan Wenhu.(2015).designsynthesisandbiologicalevaluationofacylhydrazonederivativesaspi3kinhibitors.chinesechemicalletters,26(1),118.
MLA	Gao Guorui,et al."designsynthesisandbiologicalevaluationofacylhydrazonederivativesaspi3kinhibitors".chinesechemicalletters 26.1(2015):118.