acontinuedsagaofboc5thefirstnonpeptidicglucagonlikepeptide1receptoragonistwithinvivoactivities

	acontinuedsagaofboc5thefirstnonpeptidicglucagonlikepeptide1receptoragonistwithinvivoactivities
	He Min 1; Guan Ni 1; Gao Weiwei 1; Liu Qing 1; Wu Xiaoyan 1; Ma Dawei 2; Zhong Dafang 1; Ge Guangbo 3; Li Chuan 1; Chen Xiaoyan 1
刊名	actapharmacologicasinica
	2012
卷号	33 期号:2 页码:148
关键词	Type 2 diabetes Glucagon-like peptide-1 Non-peptidic agonist Boc5 G-protein coupled receptor
ISSN号	1671-4083
英文摘要	Glucagon-like peptide-1 (GLP-1)-based therapy presents a promising option for treatingtype 2 diabetes. However, there are several limitations relative to the peptidic GLP-1mimetics currently on the market or under development. This concern has led to a continuedinterest in the search for non-peptidic agonists for GLP-1 receptor (GLP-1R). Here, webriefly review the discovery, characterization and current status of a novel class ofcyclobutane-derivative-based non-peptidic agonists for GLP-1R, including Boc5 and itsnewly discovered analogue WB4–24. Although the oral bioavailability of suchcompounds still poses great challenges, the progress made so far encourages us to identifya truly 'druggable' small molecule agonist for GLP-1R.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/284094]
专题	中国科学院上海药物研究所
作者单位	1.中国科学院上海药物研究所 2.中国科学院上海有机化学研究所 3.中国科学院大连化学物理研究所
推荐引用方式 GB/T 7714	He Min,Guan Ni,Gao Weiwei,et al. acontinuedsagaofboc5thefirstnonpeptidicglucagonlikepeptide1receptoragonistwithinvivoactivities[J]. actapharmacologicasinica,2012,33(2):148.
APA	He Min.,Guan Ni.,Gao Weiwei.,Liu Qing.,Wu Xiaoyan.,...&Wang Mingwei.(2012).acontinuedsagaofboc5thefirstnonpeptidicglucagonlikepeptide1receptoragonistwithinvivoactivities.actapharmacologicasinica,33(2),148.
MLA	He Min,et al."acontinuedsagaofboc5thefirstnonpeptidicglucagonlikepeptide1receptoragonistwithinvivoactivities".actapharmacologicasinica 33.2(2012):148.