anewsyntheticmethodofnaturalproducttrichostatina

	anewsyntheticmethodofnaturalproducttrichostatina
	Zhao X(赵曦); Zhang SL(张士磊); Duan WH(段文虎)
刊名	chinesejournaloforganicchemistry
	2007
卷号	27 期号:12 页码:1509
关键词	HISTONE DEACETYLASE INHIBITORS FRIEND LEUKEMIC-CELLS POTENT DIFFERENTIATION ENZYME trichostatin A histone deacetylase inhibitor L-proline synthesis
ISSN号	0253-2786
英文摘要	An efficient synthesis of trichostatin A, A potent histone deacetylase inhibitor, was reported. The key point in this new approach lied in the highly stereocontrolled establishment of its chiral center using L-proline-catalyzed aldol reaction between p-nitrobenzaldehyde and propaidehyde. The aldol product was obtained with >99% ee and high de (anti : syn =16 : 1). No racemization was found in the following process and the synthetic trichostatin A was a pure R enantiomer with more than 99% ee.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/283632]
专题	中国科学院上海药物研究所
作者单位	中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Zhao X,Zhang SL,Duan WH. anewsyntheticmethodofnaturalproducttrichostatina[J]. chinesejournaloforganicchemistry,2007,27(12):1509.
APA	赵曦,张士磊,&段文虎.(2007).anewsyntheticmethodofnaturalproducttrichostatina.chinesejournaloforganicchemistry,27(12),1509.
MLA	赵曦,et al."anewsyntheticmethodofnaturalproducttrichostatina".chinesejournaloforganicchemistry 27.12(2007):1509.