anewsyntheticmethodofnaturalproducttrichostatina | |
Zhao X(赵曦); Zhang SL(张士磊); Duan WH(段文虎) | |
刊名 | chinesejournaloforganicchemistry
![]() |
2007 | |
卷号 | 27期号:12页码:1509 |
关键词 | HISTONE DEACETYLASE INHIBITORS FRIEND LEUKEMIC-CELLS POTENT DIFFERENTIATION ENZYME trichostatin A histone deacetylase inhibitor L-proline synthesis |
ISSN号 | 0253-2786 |
英文摘要 | An efficient synthesis of trichostatin A, A potent histone deacetylase inhibitor, was reported. The key point in this new approach lied in the highly stereocontrolled establishment of its chiral center using L-proline-catalyzed aldol reaction between p-nitrobenzaldehyde and propaidehyde. The aldol product was obtained with >99% ee and high de (anti : syn =16 : 1). No racemization was found in the following process and the synthetic trichostatin A was a pure R enantiomer with more than 99% ee. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/283632] ![]() |
专题 | 中国科学院上海药物研究所 |
作者单位 | 中国科学院上海药物研究所 |
推荐引用方式 GB/T 7714 | Zhao X,Zhang SL,Duan WH. anewsyntheticmethodofnaturalproducttrichostatina[J]. chinesejournaloforganicchemistry,2007,27(12):1509. |
APA | 赵曦,张士磊,&段文虎.(2007).anewsyntheticmethodofnaturalproducttrichostatina.chinesejournaloforganicchemistry,27(12),1509. |
MLA | 赵曦,et al."anewsyntheticmethodofnaturalproducttrichostatina".chinesejournaloforganicchemistry 27.12(2007):1509. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论