cembranetypediterpenoidsfromthesouthchinaseasoftcoralsarcophytonmililatensis

	cembranetypediterpenoidsfromthesouthchinaseasoftcoralsarcophytonmililatensis
	Li Songwei 1; Ye Fei 1; Zhu Zhengdan 1; Huang Hui 2; Mao Shuichun 3; Guo Yuewei 1
刊名	actapharmaceuticasinicab
	2018
卷号	000 期号:006 页码:944
关键词	Soft coral Sarcophyton Sarcophyton mililatensis Cembrane-type diterpenoids Modified Mosher’s method ECD calculation Cytotoxicity NF-κB inhibitory activity
ISSN号	2211-3835
英文摘要	Eight cembrane-type diterpenoids, namely,（t）-（6 R）-6-hydroxyisosarcophytoxide（1）,（t）-（6 R）-6-acetoxyisosarcophytoxide（2）,（t）-17-hydroxyisosarcophytoxide（3）, sarcomililatins A–D（4–7）, and sarcomililatol（8）, were isolated from the soft coral Sarcophyton mililatensis collected from Weizhou Island, Guangxi Autonomous Region, together with 2 known related analogues,（t）-isosarcophytoxide（9） and（t）-isosarcophine（10）. The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data.The absolute configuration of compound 1 was established by the modified Mosher’s method, while the absolute configurations of compounds 4 and 5 were assigned by electronic circular dichroism（ECD）spectroscopy and that of compound 8 was established by time-dependent density functional theory electronic circular dichroism（TD-DFT ECD） calculation. In in vitro bioassays, compound 9 displayed significant cytotoxicity against the human cancer cell lines human promyelocytic leukemia cells（HL-60）and human lung adenocarcinoma cells（A-549） with IC50 values of 0.7870.21 and 1.2670.80 μmol/L,respectively. Compounds 4 and 9 also showed moderate inhibitory effects on the TNFα-induced Nuclear factor kappa B（NF-κB, a therapeutical target in cancer） activation, showing IC50 values of 35.23712.42 and 22.5274.44 μmol/L, respectively.
资助项目	[Natural Science Foundation of China] ; [NSFC-Shandong Joint Fund for Marine Science Research Centers] ; [SCTSM Project] ; [SKLDR/SIMM Projects]
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/283009]
专题	中国科学院上海药物研究所
作者单位	1.中国科学院上海药物研究所 2.中国科学院南海海洋研究所 3.School of Pharmacy,Nanchang University
推荐引用方式 GB/T 7714	Li Songwei,Ye Fei,Zhu Zhengdan,et al. cembranetypediterpenoidsfromthesouthchinaseasoftcoralsarcophytonmililatensis[J]. actapharmaceuticasinicab,2018,000(006):944.
APA	Li Songwei,Ye Fei,Zhu Zhengdan,Huang Hui,Mao Shuichun,&Guo Yuewei.(2018).cembranetypediterpenoidsfromthesouthchinaseasoftcoralsarcophytonmililatensis.actapharmaceuticasinicab,000(006),944.
MLA	Li Songwei,et al."cembranetypediterpenoidsfromthesouthchinaseasoftcoralsarcophytonmililatensis".actapharmaceuticasinicab 000.006(2018):944.