synthesischaracterizationandantitumoractivitiesofconicuzncomplexeswith14710tetrakis4nitrobenzyl14710tetraazacyclododecanemacrocyclicligand

	synthesischaracterizationandantitumoractivitiesofconicuzncomplexeswith14710tetrakis4nitrobenzyl14710tetraazacyclododecanemacrocyclicligand
	Huang Xiaoying 1; Kong Deyuan 2; Xie Yuli 2; Xie Yuyuan 2
刊名	结构化学
	2000
卷号	19 期号:1 页码:39
关键词	LANTHANIDE COMPLEXES MOLECULAR-STRUCTURE PHOSPHATE DIESTER EUROPIUM(III) LANTHANUM(III) ALCOHOL CRYSTAL RNA CONFORMATION CLEAVAGE synthesis macrocyclic ligand antitumor activity crystal structure
ISSN号	0254-5861
英文摘要	New tetraazamacrocyclic ligand with 1, 4, 7, 10-tetrakis (4-nitrobenzyl) pendent groups (C36H40N8O8, M-r = 712. 76) crystallized in the monoclinic system, P2(1)/n space group with unit cell parameters: a = 7. 834(2), b = 22. 902(6) , c = 10. 147(3)Angstrom, beta = 106. 53(2)degrees, V = 1715(1) Angstrom (3), Z = 2, D-c= 1. 356 g/cm(3) (,) lambda(Mo-k alpha) = 0. 71069 Angstrom; mu = 0. 92cm(-1), F(000) = 752, T = 296K. The final R and R-w values are 0. 065 and 0. 066, respectively. The Cu( I ), Nit ( I ), Co( I ), Zn( I ) complexes with this new ligand have been synthesized and characterized by elemental analyses, IR, UV, ESI-MS and molar conductance, The macrocyclic ligand molecular structure is centrosymmetrical. All complexes are in accordance with the general formula: M(L)(NO3)(2) . nH(2)O (M = Co, Ni, Cu, n = 2; M = Zn, n = 4; L = C36H40-N8O8). The central metal ions coordinate to four nitrogen atoms of azamacrocycle and two oxygen atoms of one nitrate ion. Preliminary pharmacological tests against P-388 and A-549 tumor cell lines showed that all these complexes had considerable activities in vitro.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282988]
专题	中国科学院上海药物研究所
作者单位	1.Rugters University 2.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Huang Xiaoying,Kong Deyuan,Xie Yuli,et al. synthesischaracterizationandantitumoractivitiesofconicuzncomplexeswith14710tetrakis4nitrobenzyl14710tetraazacyclododecanemacrocyclicligand[J]. 结构化学,2000,19(1):39.
APA	Huang Xiaoying,Kong Deyuan,Xie Yuli,&Xie Yuyuan.(2000).synthesischaracterizationandantitumoractivitiesofconicuzncomplexeswith14710tetrakis4nitrobenzyl14710tetraazacyclododecanemacrocyclicligand.结构化学,19(1),39.
MLA	Huang Xiaoying,et al."synthesischaracterizationandantitumoractivitiesofconicuzncomplexeswith14710tetrakis4nitrobenzyl14710tetraazacyclododecanemacrocyclicligand".结构化学 19.1(2000):39.