Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives

doi:10.1016/j.bmcl.2019.126685

	Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives
	Wang, Zhenkang 3; Ma, Chunhua 1; Wang, Yujie 3; Xiao, Qiang 3; Xu, Chenghui 2; Li, Yingxia 3
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2019-11-15
卷号	29 期号:22 页码:6
关键词	Gentisides Neurotrophic activity Isosteric replacement Conformational restriction PC 12 cells
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2019.126685
通讯作者	Li, Yingxia(liyx417@fudan.edu.cn)
英文摘要	C14 alkyl benzoate ABG001, derived from naturally occurring gentisides, was reported to exhibit neurotrophic activity which is similar to NGF (Nerve Growth Factor). In this research, ABG001 was modified by the strategy of isosteric replacement and conformational restriction with the purpose of improving the bioactivity. The cellular neurotrophic activity of those ABG001 derivatives were evaluated, among which 3-hydroxyquinolin-2-(1H)-one A3 and 4-decylphenol ester B7 displayed much better neurotrophic activity compared with ABG001, which highlights the potential of those novel scaffolds for future neurotrophic agent development.
资助项目	National Natural Science Foundation of China[81773576]
WOS关键词	NEURITE OUTGROWTH ; NEURODEGENERATION
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000490741500012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282690]
专题	中国科学院上海药物研究所
通讯作者	Li, Yingxia
作者单位	1.Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Sch Chem & Chem Engn, Key Lab Green Chem Media & React,Minist Educ, Xinxiang 453007, Henan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhenkang,Ma, Chunhua,Wang, Yujie,et al. Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2019,29(22):6.
APA	Wang, Zhenkang,Ma, Chunhua,Wang, Yujie,Xiao, Qiang,Xu, Chenghui,&Li, Yingxia.(2019).Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,29(22),6.
MLA	Wang, Zhenkang,et al."Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 29.22(2019):6.